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Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors
- Y. Zhang, Shaohua Xu, +9 authors Y. Zhang
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 4 October 2010
Salicylic acid (SA) is a defense hormone required for both local and systemic acquired resistance (SAR) in plants. Pathogen infections induce SA synthesis through up-regulating the expression of… Expand
Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblasts Revealed by Microarray and Bioinformatics*
Parathyroid hormone (PTH) binds to its receptor PTH1R (parathyroid hormone 1 receptor) in osteoblastic cells to regulate bone remodeling and calcium homeostasis. While prolonged exposure to PTH… Expand
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2',5' cGAMP, that binds to STING… Expand
Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation*
- L. Qin, J. Tamasi, +5 authors N. Partridge
- Medicine, Biology
- Journal of Biological Chemistry
- 4 February 2005
Parathyroid hormone (PTH) is the major mediator of calcium homeostasis and bone remodeling and is now known to be an effective drug for osteoporosis treatment. Yet the mechanisms responsible for its… Expand
Paternal genetic affinity between western Austronesians and Daic populations
BackgroundAustronesian is a linguistic family spread in most areas of the Southeast Asia, the Pacific Ocean, and the Indian Ocean. Based on their linguistic similarity, this linguistic family… Expand
Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene.
LH/hCG receptors were disrupted by gene targeting in embryonic stem cells. The disruption resulted in infertility in both sexes. The gonads contained no receptor mRNA or receptor protein. Serum LH… Expand
MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.
Many members of the TGF-beta superfamily are indicated to play important roles in ovarian follicular development, such as affecting granulosa cell function and oocyte maturation. Abnormalities… Expand
Link prediction approach to collaborative filtering
Recommender systems can provide valuable services in a digital library environment, as demonstrated by its commercial success in book, movie, and music industries. One of the most commonly-used and… Expand
MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin.
MicroRNAs (miRNAs) may function as oncogenes or tumor suppressors. Here, we show that miR-27a is up-regulated in human gastric adenocarcinoma. Suppression of miR-27a inhibits gastric cancer cell… Expand
MicroRNA‐9 inhibits ovarian cancer cell growth through regulation of NF‐κB1
MicroRNAs are emerging as important regulators of cancer‐related processes. Our studies show that microRNA‐9 (miR‐9) is downregulated in human ovarian cancer relative to normal ovary, and… Expand