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Early motor activity drives spindle bursts in the developing somatosensory cortex
TLDR
It is suggested that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination. Expand
GABAA, NMDA and AMPA receptors: a developmentally regulated `ménage à trois'
TLDR
Determining the mechanisms underlying the development of this 'ménage à trois' will shed light not only on the wide range of trophic roles of glutamate and GABA in the developing brain, but also on the significance of the transition from neonatal to adult forms of plasticity. Expand
Temporal Interaction between Single Spikes and Complex Spike Bursts in Hippocampal Pyramidal Cells
TLDR
It is suggested that bursts may function as "conditional synchrony detectors," signaling strong afferent synchrony after neuronal silence, and that single spikes triggered by a weak input may suppress bursts evoked by a subsequent strong input. Expand
Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells
TLDR
It is suggested that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes. Expand
Correlated Bursts of Activity in the Neonatal Hippocampus in Vivo
TLDR
Recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups may underlie activity-dependent maturation of the hippocampal network. Expand
Ca2+ Oscillations Mediated by the Synergistic Excitatory Actions of GABAA and NMDA Receptors in the Neonatal Hippocampus
TLDR
Network-driven Giant Depolarizing Potentials, which are a typical feature of the neonatal hippocampal network, provided coactivation of GABA(A) and NMDA receptors and were associated with spontaneous and synchronous Ca2+ increases in CA3 pyramidal neurons, indicating GABA is a major excitatory transmitter that acts in synergy withNMDA receptors at the early stages of development. Expand
A Long-Lasting Calcium-Activated Nonselective Cationic Current Is Generated by Synaptic Stimulation or Exogenous Activation of Group I Metabotropic Glutamate Receptors in CA1 Pyramidal Neurons
TLDR
It is proposed that the synaptic ICAN, activated by a brief tetanic stimulation and leading to a long-lasting inward current, may be involved in neuronal plasticity and synchronized network-driven oscillations. Expand
Synchronization of GABAergic interneuronal network in CA3 subfield of neonatal rat hippocampal slices.
TLDR
It is concluded that synchronous activation of SR‐CA3 interneurons during generation of GDPs is mediated synaptically and is determined by the co‐operation of excitatory GABAergic connections between interneerons and glutamatergic connections to interneURons originating presumably from the pyramidal cells. Expand
Hebbian modification of a hippocampal population pattern in the rat
TLDR
The findings show that the Hebbian pairing of cellular activation with spontaneous, naturally occurring synaptic events is capable of inducing LTP. Expand
Synaptic GABAA activation induces Ca2+ rise in pyramidal cells and interneurons from rat neonatal hippocampal slices.
TLDR
It is demonstrated here that in neonatal (P2‐5) hippocampus, GABA is an excitatory neurotransmitter which can cause an elevation of [Ca2+]i in interneurons and pyramidal cells via activation of voltage‐dependent Ca2+ channels. Expand
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