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Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium.
- X. Lei, J. K. Evenson, K. M. Thompson, R. Sunde
- Biology, ChemistryThe Journal of nutrition
- 1 June 1995
It is demonstrated that these two selenoperoxidases are differentially regulated by dietary Se, and liver and heart GPX1 mRNA levels were reduced and PHGPX mRNA was not significantly affected by Se deficiency.
Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
- J. McClung, C. Roneker, X. Lei
- Biology, MedicineProceedings of the National Academy of Sciences…
- 7 June 2004
The development of insulin resistance in mammals with elevated expression of an antioxidant enzyme is reported and it is suggested that increased GPX1 activity may interfere with insulin function by overquenching intracellular reactive oxygen species required for insulin sensitizing.
Metabolic regulation and function of glutathione peroxidase-1.
Data is accumulating to link alteration or abnormality of GPX1 expression to etiology of cancer, cardiovascular disease, neurodegeneration, autoimmune disease, and diabetes, and future research should focus on the mechanism of GPx1 in the pathogeneses and potential applications ofGPX1 manipulation in the treatment of these disorders.
Phytase, a new life for an "old" enzyme.
- X. Lei, Jeremy D. Weaver, E. Mullaney, A. H. Ullah, M. Azain
- BiologyAnnual review of animal biosciences
- 25 February 2013
This chapter provides a comprehensive review of the evolving course of phytase science and technology and gives realistic estimates of the versatile roles ofphytase in animal feeding, environmental protection, rock phosphorus preservation, human nutrition and health, and industrial applications.
Efficacy of an E. coli phytase expressed in yeast for releasing phytate-bound phosphorus in young chicks and pigs.
Four chick trials and one pig trial were conducted to investigate the phosphorus-releasing efficacy oftwo commercial phytase enzymes (Natuphos and Ronozyme) and an experimental E. coli phytase enzyme…
Dietary inulin affects the expression of intestinal enterocyte iron transporters, receptors and storage protein and alters the microbiota in the pig intestine
- E. Tako, R. Glahn, Ross M. Welch, X. Lei, K. Yasuda, D. Miller
- BiologyBritish Journal of Nutrition
- 1 March 2008
Results indicate that dietary inulin might trigger an up regulation of genes encoding for Fe transporters in the enterocyte, and the specific mechanism for this effect remains to be elucidated.
Phytase enzymology, applications, and biotechnology
This review covers the basic biochemistry and application of phytase, and emphasizes the emerging biotechnology used for developing new effective phytases with improved properties.
Role of glycosylation in the functional expression of an Aspergillus niger phytase (phyA) in Pichia pastoris.
Glycosylation was vital to the biosynthesis of the phyA phytase in P. pastoris and the thermostability of the expressed enzyme.
Supplementing corn-soybean meal diets with microbial phytase linearly improves phytate phosphorus utilization by weanling pigs.
- X. Lei, P. K. Ku, E. R. Miller, M. Yokoyama
- Chemistry, MedicineJournal of animal science
- 1 December 1993
Two experiments were conducted with weanling pigs to determine the effectiveness of a dietary supplement of Aspergillus niger phytase in improving the availability of phytate-P in corn-soybean meal…
Cloning, sequencing, and expression of an Escherichia coli acid phosphatase/phytase gene (appA2) isolated from pig colon.
The DNA fragment isolated from E. coli in pig colon seems to encode for a new acid phosphatase/phytase and is designated as E. bacteria appA2, a recombinant protein that was able to hydrolyze phosphorus from sodium phytate and p-nitrophenyl phosphate.