• Publications
  • Influence
Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury
  • G. Wang, J. Zhang, +7 authors J. Chen
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 14 August 2013
Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific roles of microglia/macrophages in traumatic brainExpand
  • 276
  • 15
Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R inducesExpand
  • 140
  • 9
Blood-brain barrier dysfunction and recovery after ischemic stroke
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes and cells at the blood-brain interface and maintaining the homeostatic microenvironment of the CNS.Expand
  • 116
  • 9
HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
  • G. Wang, Yejie Shi, +11 authors J. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 17 February 2015
Significance Moderate or severe traumatic brain injury (TBI) damages white matter, thereby contributing to long-term neurological deficits. Currently, there are no satisfactory therapies to mitigateExpand
  • 189
  • 7
  • Open Access
A novel role of phospholipase A2 in mediating spinal cord secondary injury
To investigate whether phospholipase A2 (PLA2) plays a role in the pathogenesis of spinal cord injury (SCI).
  • 117
  • 6
Scriptaid, a Novel Histone Deacetylase Inhibitor, Protects Against Traumatic Brain Injury via Modulation of PTEN and AKT Pathway
Traumatic brain injury (TBI) is a leading cause of motor and cognitive deficits in young adults for which there is no effective therapy. The present study characterizes the protective effect of a newExpand
  • 71
  • 4
Garlic‐derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC‐7901 tumor‐bearing mice
Abstract Diallyl trisulfide (DATS), a natural agent derived from garlic, has been tested for its antigastric cancer activities in various preliminary studies. However, more systematic pharmacodymaticExpand
  • 13
  • 3
Investigating siRNA delivery to chronic myeloid leukemia K562 cells with lipophilic polymers for therapeutic BCR-ABL down-regulation.
RNAi represents a new alternative for treatment of chronic myeloid leukemia (CML) to overcome the difficulties of current drug treatments such as the acquired resistance. However, potent carriersExpand
  • 37
  • 2
A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia
White matter injury induced by ischemic stroke elicits sensorimotor impairments, which can be further deteriorated by persistent proinflammatory responses. We previously reported that delayed andExpand
  • 31
  • 2
Drug Metabolism and Pharmacokinetics of Organosulfur Compounds from Garlic
The medicinal activities of garlic organosulfur compounds identified include antitumor, antimicrobial, antifungal, antivirus, anti-atherosclerosis, blood lipids and sugar lowering, antithrombotic,Expand
  • 32
  • 2