• Publications
  • Influence
NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging
An RNA structural switch regulates whether the HIV genome is translated or dimerized and packaged. The 5′-leader of the HIV-1 genome regulates multiple functions during viral replication viaExpand
Structural determinants and mechanism of HIV-1 genome packaging.
Like all retroviruses, the human immunodeficiency virus selectively packages two copies of its unspliced RNA genome, both of which are utilized for strand-transfer-mediated recombination duringExpand
Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.
Assembly of human immunodeficiency virus type 1 (HIV-1) particles is initiated in the cytoplasm by the formation of a ribonucleoprotein complex comprising the dimeric RNA genome and a small number ofExpand
Structure of the HIV-1 RNA packaging signal
Structural signals that direct HIV packaging During the viral replication cycle of HIV, unspliced dimeric RNA genomes are efficiently packaged into new virions at the host cell membrane. Packaging isExpand
DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity.
Cellular RNA-binding proteins incorporated into virions during human immunodeficiency virus type 1 (HIV-1) assembly promote the replication efficiency of progeny virions. Despite its critical role inExpand
Infectivity of SARS-CoV-2: there Is Something More than D614G?
Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCoV-2), causative agent of Coronavirus Disease 19 (COVID19), has spread throughout the world since its first emergence in Dec. 2019 in Wuhan,Expand
DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA
Significance Diversity-generating retroelements (DGRs) are in vivo sequence diversification machines that are widely distributed in bacteria, archaea, and their viruses. DGRs use a reverseExpand
Database proton NMR chemical shifts for RNA signal assignment and validation
The Biological Magnetic Resonance Data Bank contains NMR chemical shift depositions for 132 RNAs and RNA-containing complexes. We have analyzed the 1H NMR chemical shifts reported forExpand
Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKU1 leads to the common cold, short lasting rhinitis,Expand
Virion-associated, host-derived DHX9/RNA helicase A enhances the processivity of HIV-1 reverse transcriptase on genomic RNA
DHX9/RNA helicase A (RHA) is a host RNA helicase that participates in many critical steps of the HIV-1 life cycle. It co-assembles with the viral RNA genome into the capsid core. Virions deficient inExpand