• Publications
  • Influence
Rapid Subfunctionalization Accompanied by Prolonged and Substantial Neofunctionalization in Duplicate Gene Evolution
Gene duplication is the primary source of new genes. Duplicate genes that are stably preserved in genomes usually have divergent functions. The general rules governing the functional divergence,Expand
  • 587
  • 30
  • PDF
RNA sequencing shows no dosage compensation of the active X-chromosome
Mammalian cells from both sexes typically contain one active X chromosome but two sets of autosomes. It has previously been hypothesized that X-linked genes are expressed at twice the level ofExpand
  • 171
  • 18
  • PDF
Why Do Hubs Tend to Be Essential in Protein Networks?
The protein–protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hubExpand
  • 558
  • 14
  • PDF
Gene Complexity and Gene Duplicability
Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higherExpand
  • 93
  • 13
  • PDF
Toward a Molecular Understanding of Pleiotropy
Pleiotropy refers to the observation of a single gene influencing multiple phenotypic traits. Although pleiotropy is a common phenomenon with broad implications, its molecular basis is unclear. UsingExpand
  • 186
  • 9
  • PDF
Expression reduction in mammalian X chromosome evolution refutes Ohno’s hypothesis of dosage compensation
Susumu Ohno proposed in 1967 that, during the origin of mammalian sex chromosomes from a pair of autosomes, per-allele expression levels of X-linked genes were doubled to compensate for theExpand
  • 97
  • 9
  • PDF
Higher duplicability of less important genes in yeast genomes.
  • X. He, J. Zhang
  • Biology, Medicine
  • Molecular biology and evolution
  • 2006
Gene duplication plays an important role in evolution because it is the primary source of new genes. Many recent studies showed that gene duplicability varies considerably among genes. SeveralExpand
  • 76
  • 8
  • PDF
Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes
Nucleosome Maps and Mutation Understanding the processes governing the accumulation of mutations impacts many facets of evolutionary biology. Combining data from a mutation accumulation experiment inExpand
  • 72
  • 6
Significant impact of protein dispensability on the instantaneous rate of protein evolution.
  • J. Zhang, X. He
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 April 2005
The neutral theory of molecular evolution predicts that important proteins evolve more slowly than unimportant ones. High-throughput gene-knockout experiments in model organisms have providedExpand
  • 113
  • 4
  • PDF
Measuring the evolutionary rate of protein–protein interaction
Despite our extensive knowledge about the rate of protein sequence evolution for thousands of genes in hundreds of species, the corresponding rate of protein function evolution is virtually unknown,Expand
  • 47
  • 4
  • PDF