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Gossypol induces Bax/Bak‐independent activation of apoptosis and cytochrome c release via a conformational change in Bcl‐2
It is concluded that gossypol converts the antiapoptotic molecule Bcl‐2 into a proapoptosis molecule that can mediate the release of cyto c and induce apoptosis.
Effect of total phenolics from Laggera alata on acute and chronic inflammation models.
Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses
Evidence is provided that a class of compounds, seco-pregnane steroid glaucogenin C and its monosugar-glycoside cynatratoside A of Strobilanthes cusia and three new pantasugar- glycosides of glaucgenin C of Cynanchum paniculatum, are effective and selective inhibitors to alphavirus-like positive-strand RNA viruses, but not to other RNA or DNA viruses.
3-Acetonyl-3-hydroxyoxindole: a new inducer of systemic acquired resistance in plants.
The data suggest that AHO may represent a novel class of inducer that stimulates SA-mediated defence responses, and its ability to induce PR-1 expression and TMV resistance in nahG transgenic plants expressing salicylate hydroxylase, which prevents the accumulation of SA was analysed.
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
A diterpenoid derivative 15-oxospiramilactone (S3) is identified that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2.
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis
It is demonstrated that NC043 is a novel small molecule that inhibits canonical Wnt signaling downstream of β-catenin stability and may be a potential compound for treating colorectal cancer.
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction.
This study provides new insights into the regulation of the Wnt/β-catenin signaling pathway by a Wnt-specific small molecule but also will facilitate therapeutic applications, such as HSC expansion, by screening a synthetic chemical library of lycorine derivatives.
Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
This work has investigated the mode of cell death induced by fangchinoline and its underlying mechanism in two human hepatocellular carcinoma cell lines, HepG2 and PLC/PRF/5.