• Publications
  • Influence
Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples.
  • X. Han, R. Gross
  • Chemistry, Medicine
  • Mass spectrometry reviews
  • 1 May 2005
Lipidomics, after genomics and proteomics, is a newly and rapidly expanding research field that studies cellular lipidomes and the organizational hierarchy of lipid and protein constituents mediatingExpand
  • 920
  • 30
Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis
In addition to pathology in the gray matter, there are also abnormalities in the white matter in Alzheimer's disease (AD). Sulfatide species are a class of myelin‐specific sphingolipids and areExpand
  • 469
  • 21
Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
  • J. Chan, X. Han, Y. Kan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 December 1993
We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designatedExpand
  • 321
  • 18
  • PDF
Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry
To explore the hypothesis that alterations in ethanolamine plasmalogen may be directly related to the severity of dementia in Alzheimer's disease (AD), we performed a systematic examination ofExpand
  • 388
  • 18
Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids.
  • X. Han, R. Gross
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 October 1994
Electrospray ionization mass spectrometry (ESI-MS) was utilized for the structural determination and quantitative analysis of individual phospholipid molecular species from subpicomole amounts ofExpand
  • 369
  • 17
Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics.
  • X. Han, R. Gross
  • Chemistry, Medicine
  • Journal of lipid research
  • 1 June 2003
Lipidomics is a rapidly expanding research field in which multiple techniques are utilized to quantitate the hundreds of chemically distinct lipids in cells and determine the molecular mechanismsExpand
  • 627
  • 12
  • PDF
Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.
  • X. Han, R. Gross
  • Chemistry, Medicine
  • Analytical biochemistry
  • 1 August 2001
Herein we describe a rapid, simple, and reliable method for the quantitative analysis and molecular species fingerprinting of triacylglycerides (TAG) directly from chloroform extracts of biologicalExpand
  • 292
  • 11
Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes
  • X. Han, R. Gross
  • Chemistry, Medicine
  • Expert review of proteomics
  • 1 April 2005
Shotgun lipidomics, comprised of intrasource separation, multidimensional mass spectrometry and computer-assisted array analysis, is an emerging powerful technique in lipidomics. Through effectiveExpand
  • 232
  • 9
Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway
Amyloid-β peptide (Aβ) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration. We have recently demonstrated that Aβ inducedExpand
  • 206
  • 9
  • PDF
Characterization of the protein Z-dependent protease inhibitor.
Protein Z-dependent protease inhibitor (ZPI) is a 72-kd member of the serpin superfamily of proteinase inhibitors that produces rapid inhibition of factor Xa in the presence of protein Z (PZ),Expand
  • 156
  • 9