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Melanin and pyomelanin in Aspergillus fumigatus: from its genetics to host interaction
TLDR
The aim of this review is to present the current knowledge of the genetic basis and metabolic pathways of melanin production, their activation, function, and interaction with the host immune system. Expand
Proteomics as a Tool to Identify New Targets Against Aspergillus and Scedosporium in the Context of Cystic Fibrosis
TLDR
Proteomics-based information was collated relating to secreted and cell wall proteins with potential medical applications from the most common filamentous fungi in CF, i.e., Aspergillus and Scedosporium/Lomentospora species, and proteins mentioned may be promising candidates for developing innovative diagnostic and therapeutic tools for fungal infections in CF patients. Expand
Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications
TLDR
This work offers a complete review of all the information currently related to the fumagillin mycotoxin secreted by A. fumigatus, important because of its role in the fungal infection process but also because it has many other applications, notably in beekeeping, the treatment of infectious diseases, and in oncology. Expand
A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus
TLDR
It is probable that A. fumigatus progresses through the lungs via the production of the mycotoxin fumagillin combined with the secretion of lytic enzymes that allow fungal growth, angioinvasion and the disruption of the lung parenchymal structure. Expand
Aspergillus fumigatus transcriptome response to a higher temperature during the earliest steps of germination monitored using a new customized expression microarray.
TLDR
A new expression microarray covering the entire genome of Aspergillus fumigatus revealed that 1249 genes were differentially expressed during growth at these two temperatures, implying that many as yet unknown genes were involved in the establishment of A. fumgatus infection. Expand
Fast SARS-CoV-2 detection protocol based on RNA precipitation and RT-qPCR in nasopharyngeal swab samples
TLDR
This simple protocol allows SARS-CoV-2 testing independently of commercial kit providers in a time and cost-effective manner and can be readily implemented in research and/or diagnostic laboratories worldwide, provided that patient confidentiality and researcher safety are ensured. Expand
Microglial immune response is impaired against the neurotropic fungus Lomentospora prolificans
TLDR
Evidence is provided for an impaired microglial response against L. prolificans and this work proved that microglia phagocytosis of the fungus is highly dependent on mannose receptor and especially on dectin‐1. Expand
Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence
TLDR
The sensing, uptake and regulation process of the acquisition of nutrients, the connections between pathways and the virulence-implicated genes are described, and a wide field of knowledge that remains uncertain and might offer new therapeutic and diagnostic targets is described. Expand
A novel SPE-UHPLC-DAD method for the determination of fumagillin produced by Aspergillus fumigatus in cell culture media
Abstract Fumagillin is a biomolecule produced by Aspergillus fumigatus that is gaining relevance due to its connection with invasive aspergillosis. The determination of this molecule might help toExpand
Mikroorganismoek minbizia eragin dezakete ? ( Can microorganisms induce cancer ? )
Many studies have analyzed relationships between microorganisms and cancer, demonstrating that microorganisms are able to prevent the onset of cancer and, others to provoke it. Specifically, more andExpand