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Copy Number Variation of Multiple Genes at Rhg1 Mediates Nematode Resistance in Soybean
TLDR
Gene silencing showed that genes in a 31-kilobase segment at rhg1-b, encoding an amino acid transporter, an α-SNAP protein, and a WI12 (wound-inducible domain) protein, each contribute to resistance against soybean cyst nematode. Expand
Mutations of genes in synthesis of the carotenoid precursors of ABA lead to pre-harvest sprouting and photo-oxidation in rice
TLDR
The results suggest that the impairment of carotenoid biosynthesis causes photo-oxidation and ABA-deficiency phenotypes, of which the latter is a major factor controlling the PHS trait in rice. Expand
EARP, a multisubunit tethering complex involved in endocytic recycling
TLDR
A tethering complex named endosome-associated recycling protein (EARP) is described that is structurally related to the previously described Golgi-associated retrograde protein (GARP) complex, but EARP contains an uncharacterized protein, syndetin, in place of the Vps54 subunit of GARP. Expand
Distinct Copy Number, Coding Sequence, and Locus Methylation Patterns Underlie Rhg1-Mediated Soybean Resistance to Soybean Cyst Nematode1[W][OPEN]
TLDR
Based on copy number variation, transcript abundance, nucleic acid polymorphisms, and differentially methylated DNA regions, it is found that SCN resistance is associated with multicopy Rhg1 haplotypes that form two distinct groups. Expand
Dock3 Stimulates Axonal Outgrowth via GSK-3β-Mediated Microtubule Assembly
TLDR
The results suggest that Dock3 plays important roles downstream of BDNF signaling in the CNS, where it regulates cell polarity and promotes axonal outgrowth by stimulating dual pathways: actin polymerization and microtubule assembly. Expand
A comprehensive analysis reveals mutational spectra and common alleles in Chinese patients with oculocutaneous albinism.
  • A. Wei, Y. Wang, +8 authors Wei Li
  • Medicine
  • The Journal of investigative dermatology
  • 1 March 2010
TLDR
It is found that the spectrum of mutational genes and alleles of OCA is population specific and provides useful information for the establishment of an optimized strategy of gene diagnosis and genetic counseling of Chinese OCA patients. Expand
Distinct Copy Number, Coding Sequence, and Locus Methylation Patterns Underlie Rhg1-Mediated Soybean Resistance to Soybean Cyst Nematode1[W][OPEN]
A multiple-gene locus in soybean conferring disease resistance has evolved three locus types defined by copy number, protein coding, expression, and DNA methylation differences. Copy number variationExpand
Signal-Mediated, AP-1/Clathrin-Dependent Sorting of Transmembrane Receptors to the Somatodendritic Domain of Hippocampal Neurons
TLDR
It is shown that somatodendritic sorting of various transmembrane receptors in rat hippocampal neurons is mediated by recognition of signals within the cytosolic domains of the proteins by the μ1A subunit of the adaptor protein-1 (AP-1) complex. Expand
Adaptor protein complexes and intracellular transport
TLDR
Dysfunction of AP complexes has been implicated in a variety of inherited disorders, including MEDNIK, enteropathy, deafness, peripheral neuropathy, ichthyosis and keratodermia, and HSP (hereditary spastic paraplegia). Expand
The rice GERMINATION DEFECTIVE 1, encoding a B3 domain transcriptional repressor, regulates seed germination and seedling development by integrating GA and carbohydrate metabolism
TLDR
Exogenous application of GA not only induced GD1 expression, but also partially rescued the dwarf phenotype of gd1, indicating that GD1 participates directly or indirectly in regulating GA and carbohydrate homeostasis, and further regulates rice seed germination and seedling development. Expand
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