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Fever with thrombocytopenia associated with a novel bunyavirus in China.
BACKGROUND Heightened surveillance of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause. Infection… Expand
Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation.
- Shuting Duan, X. Zhao, +7 authors X. Dong
- Biology, Medicine
- Biomedical and environmental sciences : BES
- 1 September 2003
OBJECTIVE The causal agent for SARS is considered as a novel coronavirus that has never been described both in human and animals previously. The stability of SARS coronavirus in human specimens and… Expand
Epidemiological characteristics of human prion diseases
Human prion diseases are a group of transmissible, progressive, and invariably fatal neurodegenerative disorders, which include Kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker… Expand
Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro
- Xiao-fan Wang, Chen-fang Dong, +8 authors X. Dong
- Biology, Medicine
- Molecular and Cellular Biochemistry
- 1 March 2008
Microtubule associated protein tau is considered to play roles in some types of human transmissible spongiform encephalopathies (TSE). In this study, the full-length and several truncated human tau… Expand
Proteomics Analyses for the Global Proteins in the Brain Tissues of Different Human Prion Diseases*
Proteomics changes of brain tissues have been described in different neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. However, the brain proteomics of human prion… Expand
Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry.
- D. Yan, C. Jin, X. Xiao, X. Dong
- Chemistry, Medicine
- Journal of biochemical and biophysical methods
- 24 April 2008
The growth thermogenic curves of Escherichia coli (E. coli) affected by berberine, coptisine and palmatine were determined quantitatively by microcalorimetry. The power-time curves of E. coli with… Expand
SARS: clinical virology and pathogenesis
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, called the SARS coronavirus (SARS‐CoV). Over 95% of well characterized cohorts of SARS have evidence of recent SARS‐CoV… Expand
Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases
Macroautophagy is an important process for removing misfolded and aggregated protein in cells, the dysfunction of which has been directly linked to an increasing number of neurodegenerative… Expand
Visual detection of pandemic influenza A H1N1 Virus 2009 by reverse-transcription loop-mediated isothermal amplification with hydroxynaphthol blue dye.
A sensitive reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for rapid visual detection of pandemic influenza A H1N1 virus infection. The reaction was… Expand
Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic… Expand