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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and small-cell lungExpand
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Novel Role for JNK as a Stress-activated Bcl2 Kinase*
Interleukin (IL)-3-induced Bcl2 phosphorylation at Ser70 may be required for its full and potent antiapoptotic activity. However, in the absence of IL-3, increased expression of Bcl2 can also prolongExpand
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Nicotine Inactivation of the Proapoptotic Function of Bax through Phosphorylation*
Nicotine-induced cell survival is associated with chemoresistance of human lung cancer cells, but our understanding of the intracellular mechanism(s) is fragmentary. Bax is a major proapoptoticExpand
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Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases.
Bcl2 phosphorylation at Ser-70 may be required for the full and potent suppression of apoptosis in IL-3-dependent myeloid cells and can result from agonist activation of mitochondrial protein kinaseExpand
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Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
Cell division is finely controlled by various molecules including small G proteins and kinases/phosphatases. Among these, Aurora B, RhoA, and the GAP MgcRacGAP have been implicated in cytokinesis,Expand
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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, whichExpand
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Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
  • R. Li, Z. Hu, +7 authors X. Deng
  • Biology, Medicine
  • Molecular Cancer Therapeutics
  • 26 July 2013
The emergence of resistance to EGF receptor (EGFR) inhibitor therapy is a major clinical problem for patients with non–small cell lung cancer (NSCLC). The mechanisms underlying tumor resistance toExpand
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A Functional Role for Nicotine in Bcl2 Phosphorylation and Suppression of Apoptosis*
Nicotine is not only a major component in tobacco but is also a survival agonist that inhibits apoptosis induced by diverse stimuli including chemotherapeutic drugs. However, the intracellularExpand
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Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions
Bcl2 functions to suppress apoptosis and retard cell cycle entry. Single-site phosphorylation at serine 70 (S70) is required for Bcl2's antiapoptotic function, and multisite phosphorylation atExpand
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Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival
ABSTRACT p53 not only functions as a transcription factor but also has a direct, apoptogenic role at the mitochondria. We have discovered that DNA damage-induced p53-Bcl2 binding is associated withExpand
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