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Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections
TLDR
Considering the recent progress made in elucidating the molecular and cellular biology of NK cells, the current situation and future possibilities with regard to NK cell–based adoptive immunotherapy are summarized. Expand
Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells.
TLDR
The results suggest that the adoptive transfer of a large number of ex vivo expanded NK cells, particularly in combination with monoclonal antibody drugs, is a useful tool for cancer immunotherapy. Expand
Antithetical effects of hemicellulase‐treated Agaricus blazei on the maturation of murine bone‐marrow‐derived dendritic cells
TLDR
ABH activated immature BMDCs, inducing up‐regulation of surface molecules, such as CD40, CD80 and major histocompatibility complex class I antigens, as well as inducing allogeneic T‐cell proliferation and T helper type 1 cell development. Expand
Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients.
TLDR
It is demonstrated that NK activities of PBMCs from breast cancer patients were significantly lower as compared with that of healthy individuals, indicating a role for immunological natural host defense mechanisms against cancer. Expand
Effective induction of melanoma‐antigen‐specific CD8+ T cells via Vγ9γδT cell expansion by CD56high+ Interferon‐α‐induced dendritic cells
TLDR
Vaccination with CD56high+ IFN‐DCs copulsed with tumor antigens and zoledronate may orchestrate the induction of various CD56+ immune cells possessing high effector functions, resulting in strong immunological responses against tumor cells. Expand
Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach
TLDR
The case of metastatic disease from breast cancer suggests that multidisciplinary therapy including an immunological approach might be a breakthrough in the treatment of refractory disease. Expand
Potential role of natural killer cells in controlling growth and infiltration of AIDS‐associated primary effusion lymphoma cells
TLDR
The results suggest that NK cells play an important role in growth and infiltration of PEL cells, and activated NK cells could be a promising immunotherapeutic tool against tumor or virus‐infected cells either alone or in combination with conventional therapy. Expand
Autologous Immune Enhancement Therapy in Recurrent Ovarian Cancer with Metastases: A Case Report
TLDR
Combining AIET with chemotherapy and other conventional treatments has been found to be effective in the experience, as reported earlier, even in patients with advanced ovarian cancer, and it is recommended this strategy be considered in treating similar cases. Expand
NK cell-based autologous immune enhancement therapy (AIET) for cancer
TLDR
The epidemiological data that show the relationship between NK activity and cancer incidence, monitoring of NK cell number and activity, anti-cancer activities of NK cells in vitro and in vivo and the effects of the combination of expanded NK cells with monoclonal antibody drugs on cancers through antibody-dependent cellular cytotoxicity are discussed. Expand
A comparative analysis of in vitro expansion of natural killer cells of a patient with autoimmune haemolytic anaemia and ovarian cancer with patients with other solid tumours.
TLDR
The in vitro expansion of NK cells was found to be significantly lower in the AIHA patient, probably the first in the literature, and further studies are required to establish the association between AIHA and NK-cell profile and in vitro Expansion, and to find common antibodies between red blood cells (RBCs) and NK cells. Expand
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