• Publications
  • Influence
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
TLDR
The poor TIL function and severe exhaustion observed in GBM highlight the need to better understand this tumor-imposed mode of T-cell dysfunction in order to formulate effective immunotherapeutic strategies targeting GBM.
Systemic Anti-CD25 Monoclonal Antibody Administration Safely Enhances Immunity in Murine Glioma without Eliminating Regulatory T Cells
TLDR
Systemic anti-CD25 administration does not entirely eliminate Tregs but does prevent Treg function, which leads to safe enhancement of tumor immunity in a murine glioma model that recapitulates the tumor-induced changes to the CD4 and Treg compartments seen in patients with malignant gliomas.
Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.
TLDR
A novel strategy to selectively prevent GVHD by depleting CD62L(+) T cells (naive and a subset of memory T cells) by allowing transfer of allogeneic recall antitumor and antimicrobial immunity without causing graft-versus-host disease.
Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.
TLDR
It is demonstrated that recombinant human growth hormone can accelerate phenotypic and functional immune reconstitution following allogeneic T-cell-depleted bone marrow transplantation in mice.
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
TLDR
This is the first report of systemic antibody-mediated T(Reg) depletion during lymphopenia and the consequent synergistic enhancement of vaccine-driven cellular responses, as well as the first demonstration that anti-IL-2Rα mAbs function differentially in nonlymphopenic versus lymphopenic contexts.
Sequestration of T-cells in bone marrow in the setting of glioblastoma and other intracranial tumors
TLDR
It is revealed that even treatment-naïve subjects and mice with GBM can harbor AIDS-level CD4 counts, as well as contracted, T cell–deficient lymphoid organs, and sequestration of T cells in bone marrow is a tumor-adaptive mode of T cell dysfunction, whose reversal may constitute a promising immunotherapeutic adjunct.
Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process.
TLDR
The data suggest that PDP can selectively deplete host alloantigen-specific T cells for GVHD prevention and immune and antileukemia function preserve.
Selective modification of antigen-specific T cells by RNA electroporation.
TLDR
These studies demonstrate the utility of RNA transfection as a simple method by which to purify and selectively modify the function of antigen-specific T cells for use in adoptive immunotherapy and provide evidence that transient expression of proteins by RNAtransfection is an efficient means of modulating the in vivo function of activated T cells.
Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.
TLDR
Higher numbers of total thymocytes and signal joint T-cell receptor excision circles were observed in the higher dose stem cell recipients, suggesting that accelerated regeneration of T cells was due to enhanced thymopoiesis.
Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation.
TLDR
The data suggest that combining stem cells from MHC-mismatched allogeneic donors is feasible, that it has beneficial effects on myeloid engraftment and T-cell phenotypic recovery, and that the long-term stable mixed chimeras are immunologically normal following T- cell-depleted bone marrow transplantation.
...
1
2
3
4
5
...