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Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11), is a potent anticancer drug that is increasingly used in chemotherapy. A frequent limiting side effectExpand
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Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats.
We have reported previously that a canalicular multispecific organic anion transporter (cMOAT) is responsible for the biliary excretion of carboxylate forms of irinotecan,Expand
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Active efflux of CPT-11 and its metabolites in human KB-derived cell lines.
To investigate the possible involvement of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and/or other glutathione S-conjugate export pump (GS-X pump) family members on theExpand
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Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).
Several organic anions are actively extruded from intestinal epithelial cells into the lumen and vascular sides. To examine the role of the multidrug resistance-associated protein (MRP) family in theExpand
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Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.
After administration of CTP-11, a camptothecin derivative exhibiting a wide spectrum of antitumor activity, dose-limiting gastrointestinal toxicity with great interpatient variability is observed.Expand
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Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats.
In our previous work, we found that the biliary excretion of the carboxylate form of irinotecan, CPT-11, on rat bile canalicular membrane consists of two components, the low-affinity one beingExpand
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Structural Characterization of Di- and Mono-Imidazolyl-Substituted 1,8-Naphthyridine Derivatives
Two imidazolyl derived 1,8-naphthyridine compounds (2,7-diimidazolyl-1,8-naphthyridine (a), and 2-benzimidazolyl-5,7-dimethyl-1,8-napthyridine (b)) were synthesized and structurally characterized byExpand