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Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice
The aim of present study was to elucidate the role of Interleukin-10 (IL-10) in the neuroprotection of hyperbaric oxygen (HBO) against traumatic brain injury (TBI) in mice. The TBI in mice was… Expand
Melatonin antagonizes hypoxia‐mediated glioblastoma cell migration and invasion via inhibition of HIF‐1α
Hypoxia is a crucial factor in tumor aggressiveness and resistance to therapy, especially in glioblastoma. Our previous results have shown that melatonin exerts antimigratory and anti‐invasive action… Expand
Melatonin inhibits tumorigenicity of glioblastoma stem‐like cells via the AKT–EZH2–STAT3 signaling axis
Glioblastoma stem‐like cells (GSCs) displaying self‐renewing and tumor‐propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor… Expand
EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression.
- X. Chen, H. Ma, Z. Wang, S. Zhang, Haoran Yang, Zhiyou Fang
- Biology, Medicine
- Cancer research
- 3 August 2017
Gliomas with mutant p53 occurring in 30% of glioma patients exhibit therapeutic resistance and poor outcomes. In this study, we identify a novel mechanism through which mutant p53 drives cancer cell… Expand
Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro.
- Fuwu Wang, H. Zhou, +9 authors A. Hao
- Chemistry, Medicine
- European journal of pharmacology
- 5 February 2015
Bone marrow mesenchymal stem cells (MSCs) have been shown great potential for cardiac regeneration. However the therapeutic efficiency has become a major obstacle due to the poor survival of… Expand
Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells
Sustaining proliferative signaling is one of the hallmarks of cancer. Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth factor that controls proliferation and differentiation of… Expand
Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma
Tumor recurrence in gliomas is partly attributed to increased epithelial–mesenchymal transition (EMT) and enhanced tumor cell dissemination in the adjacent brain parenchyma. Thus, exploring effective… Expand
Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway
- X. Chen, S. Zhang, +8 authors Zhiyou Fang
- Biology, Medicine
- Journal of experimental & clinical cancer…
- 28 June 2018
BackgroundHepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with HCC. Hypoxia triggers the… Expand
Melatonin promotes the acquisition of neural identity through extracellular‐signal‐regulated kinases 1/2 activation
Melatonin, a major pineal secretory product, exerts a range of physiological and neuroprotective effects. However, the functional significance of melatonin in determining neural identity, and the… Expand
2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation.
In order to evaluate the functional significance of palmitoylation during multi-potent neural stem/progenitor cell proliferation and differentiation, retinoic acid-induced P19 cells were used in this… Expand