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Smad4 and FAST-1 in the assembly of activin-responsive factor
- X. Chen, E. Weisberg, V. Fridmacher, Minoru Watanabe, Grace Naco, M. Whitman
- Biology, Medicine
- 4 September 1997
Results indicate that Smad4 stabilizes a ligand-stimulated Smad2-FAST-1 complex as an active DNA-binding factor. Expand
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
- M. Vedadi, D. Barsyte-Lovejoy, +29 authors Jian Jin
- Biology, Medicine
- Nature chemical biology
- 1 August 2011
UNC0638 is reported, an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets, and markedly reduced the clonogenicity of MCF7 cells and disproportionately affected several genomic loci encoding microRNAs. Expand
Regulation of CSF1 Promoter by the SWI/SNF-like BAF Complex
A model in which the BAF complex promotes Z-DNA formation which, in turn, stabilizes the open chromatin structure at the CSF1 promoter is proposed, which facilitates Z- DNA formation in a nucleosomal template in vitro. Expand
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
The results suggest that the metabolic profiles of tumors are likely to depend on both the genotype and tissue of origin and have implications regarding the design of therapies targeting tumor metabolism. Expand
Torque-speed relationship of the flagellar rotary motor of Escherichia coli.
The torque-speed relationship of the flagellar rotary motor of Escherichia coli is measured by a new method and is consistent with models in which torque is generated by a powerstroke mechanism. Expand
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Deletion analysis showed that the four-α-helix bundle of MLKL (1-130 amino acids) is sufficient to trigger necroptosis and the homo-oligomerization is required for MLKKL translocation and the signal sequence for plasma membrane location is located in the junction of the first and second α-helices ofMLKL. Expand
Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly
- M. Munson, X. Chen, A. E. Cocina, S. Schultz, F. Hughson
- Biology, Medicine
- Nature Structural Biology
- 1 October 2000
The X-ray crystal structure of a yeast syntaxin, Sso1p, has been determined and refined to 2.1 Å resolution and provided insight into the mechanism of SNARE assembly and its intramolecular and intermolecular regulation. Expand
Testis-specific TAF homologs collaborate to control a tissue-specific transcription program
It is proposed that the products of the five Drosophila genes encoding testis TAF homologs collaborate in an alternative TAF-containing protein complex to regulate a testis-specific gene expression program in primary spermatocytes required for terminal differentiation of male germ cells. Expand
Sonomyography: monitoring morphological changes of forearm muscles in actions with the feasibility for the control of powered prosthesis.
It was demonstrated that the morphological changes of forearm muscles during actions can be successfully detected by ultrasound and linearly correlated with the wrist angle, and sonomyography had potentials for the musculoskeletal control and assessment. Expand
Genetic Variability of Respiratory Syncytial Viruses (RSV) Prevalent in Southwestern China from 2006 to 2009: Emergence of Subgroup B and A RSV as Dominant Strains
- Zhi‐Yong Zhang, L. Du, +4 authors Xiao-dong Zhao
- Medicine, Biology
- Journal of Clinical Microbiology
- 10 February 2010
Data suggest that group A RSV likely predominated in southwestern China and that a new genotype of subgroup B with a 60-nucleotide insertion, named BA-like virus, became the dominant genotype in the 2008-2009 epidemic season. Expand