• Publications
  • Influence
Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation.
  • J. Zeng, Lixin Yang, +5 authors X. Jing
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 20 June 2005
TLDR
The burst release of the drugs can be avoided by using compatible drugs with polymers, and the drug release can follow nearly zero-order kinetics due to the degradation of the PLLA fibers in the presence of proteinase K. Expand
Biodegradable electrospun fibers for drug delivery.
  • J. Zeng, Xiaoyi Xu, +4 authors X. Jing
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 30 October 2003
TLDR
It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Expand
Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
Abstract Biodegradable polymers have been widely used and have greatly promoted the development of biomedical fields because of their biocompatibility and biodegradability. The development ofExpand
BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells.
  • Xiu-ling Xu, X. Chen, +4 authors X. Jing
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 12 September 2006
TLDR
The results strongly suggest that the BCNU/PEG-PLLA fibers have an effect of controlled release ofBCNU and are suitable for postoperative chemotherapy of cancers. Expand
Ultrafine medicated fibers electrospun from W/O emulsions.
Ultrafine fibers containing water-soluble drugs were successfully electrospun from water-in-oil (W/O) emulsions, in which the aqueous phase contained the water-soluble drugs and the oily phase was aExpand
Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility.
TLDR
The results of biocompatibility test showed that the g-HAP existing in the PLLA composite facilitated both adhesion and proliferation of chondrocytes on the P LLA/g-H AP composite film, implying that PLLa could be strengthened as well as toughened by g- HAP nano-particles. Expand
Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel.
TLDR
A novel anti-cancer PDC engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel (PTX) with redox and pH dual sensitive behaviors provides a useful strategy for anti-tumor drug delivery. Expand
Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds.
TLDR
The results suggest that fibrous scaffolds made of PGE and similar biomimetic blends of natural and synthetic polymers may be useful for engineering soft tissues, such as heart, lung, and blood vessels. Expand
Poly(ε-caprolactone) Polyurethane and Its Shape-Memory Property†
A series of segmented poly(e-caprolactone) polyurethanes (PCLUs) were prepared from poly(e-caprolactone) (PCL) diol, 2,4-toluene diisocyanate and ethylene glycol. The molecular weight (Mn) of PCL wasExpand
Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer.
TLDR
In vitro cytotoxicity assays against A549 human lung adenocarcinoma cell line demonstrated that the DOX + PTX co-delivered nanoparticles (Co-NPs) exhibited synergistic effect in inducing cancer cell apoptosis, indicating this co- delivery system with different functional antitumor drugs provides the clinical potential in cancer therapy. Expand
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