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BMP4 initiates human embryonic stem cell differentiation to trophoblast
The excitement and controversy surrounding the potential role of human embryonic stem (ES) cells in transplantation therapy have often overshadowed their potentially more important use as a basicExpand
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples, and 895 genes were identified that are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype. Expand
Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
The results suggest that β-arrestin signaling and recruitment can be simultaneously a significant contributor to antipsychotic efficacy and protective against motoric side effects. Expand
Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.
  • S. Yan, X. Chen, +7 authors M. Smith
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2 August 1994
It is proposed that in Alzheimer disease, AGEs in paired helical filament tau can induce oxidant stress, thereby promoting neuronal dysfunction, and being ideal substrates for nonenzymatic glycation. Expand
Decoding global gene expression programs in liver cancer by noninvasive imaging
It is shown that dynamic imaging traits in non-invasive computed tomography systematically correlate with the global gene expression programs of primary human liver cancer, enabling noninvasive, serial and frequent molecular profiling for personalized medicine. Expand
Abundance and community structure of ammonia-oxidizing archaea and bacteria in an acid paddy soil
The results suggested that the AOA were more sensitive than AOB to different fertilization treatments in the acid red paddy soil. Expand
Distinct pathways of genomic progression to benign and malignant tumors of the liver
Insight is offered into hepatic tumorigenesis, mouse models that should be useful in the further study of hepatic tumors and for preclinical testing are provided, and a subset of human hepatocellular carcinomas is identified that may be susceptible to combination therapy directed against Met and the Wnt signaling pathway. Expand
Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury
The microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury has shown that some microRNA such as miR-21 could be involved in the intricate process of TBI course. Expand
Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages
Tumor-derived exosomal miR-222-3p is proposed to be an effective regulator in the polarization of tumor-promoting M2 macrophages and may be a biomarker of EOC. Expand
Ecological mechanisms underlying the sustainability of the agricultural heritage rice–fish coculture system
  • J. Xie, Liangliang Hu, +7 authors X. Chen
  • Environmental Science, Medicine
  • Proceedings of the National Academy of Sciences
  • 14 November 2011
It is documented that a mutually beneficial relationship between rice and fish develops in RF: Fish reduce rice pests and rice favors fish by moderating the water environment, resulting in low N fertilizer application and low N release into the environment. Expand