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RWRMDA: predicting novel human microRNA-disease associations.
Recently, more and more research has shown that microRNAs (miRNAs) play critical roles in the development and progression of various diseases, but it is not easy to predict potential human… Expand
Drug-target interaction prediction by random walk on the heterogeneous network.
Network-based Random Walk with Restart on the heterogeneous network (NRWRH) is developed to predict potential drug-target interactions on a large scale under the hypothesis that similar drugs often target similar target proteins and the framework of Random Walk. Expand
WBSMDA: Within and Between Score for MiRNA-Disease Association prediction
Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles of miRNAs in… Expand
Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition.
The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), the prototypical reaction of click chemistry, is accelerated by tris(triazolylmethyl)amine-based ligands. Herein, we compare two new… Expand
A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis
The specific volatile organic compounds (VOCs) exhaled by lung cancer cells in the microenvironment are the source biomarkers of lung cancer and also serve as direct evidence that the diagnosis of… Expand
The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli.
The widely conserved multiple antibiotic resistance regulator (MarR) family of transcription factors modulates bacterial detoxification in response to diverse antibiotics, toxic chemicals or both.… Expand
Colorimetric detection of microcystin-LR based on disassembly of orient-aggregated gold nanoparticle dimers.
Recently we demonstrated oriented formation of gold nanoparticle (AuNP) dimers for ultrasensitive sensing oligonucleotides (J. Am. Chem. Soc. 2013, 135, 12338). Herein, we investigate the reverse… Expand
Metabolic labeling of sialic acids in living animals with alkynyl sugars.
Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment… Expand
The chaperoning properties of mouse grp170, a member of the third family of hsp70 related proteins.
- J. Park, D. Easton, X. Chen, I. Macdonald, X. Wang, J. Subjeck
- Medicine, Chemistry
- 23 December 2003
The 170 kDa glucose-regulated protein (grp170) is an endoplasmic reticulum resident protein that shares some sequence homology with both the hsp70 and hsp110 heat shock protein (hsp) families, yet is… Expand
Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch
The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly… Expand