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Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individuals.
An alert of Mycobacterium tuberculosis infection of rhesus macaques in a wild zoo in China
The report of an infectious disease among 84 rhesus macaques at a Chinese zoo emphasizes the need to strengthen the management and training of staff, especially those working at animal shelters.
The treatment of mice infected with multi-drug-resistant Mycobacterium tuberculosis using DNA vaccines or in combination with rifampin.
Immune responses to latent tuberculosis antigen Rv2659c in Chinese populations.
Treatment of Multi‐Drug‐Resistant Tuberculosis in Mice with DNA Vaccines Alone or in Combination with Chemotherapeutic Drugs
The effects of Ag85A DNA vaccine alone or in combination with rifampin (RFP) or pyrazinamide (PZA) for the treatment of MDR‐TB in mice were studied.
Immunogenicity and therapeutic effects of Ag85A/B chimeric DNA vaccine in mice infected with Mycobacterium tuberculosis.
- Yan Liang, Xueqiong Wu, Xiaoli Wu
- Biology, MedicineFEMS immunology and medical microbiology
- 1 December 2012
Results show that Ag85A/B chimeric DNA was effective for the treatment of TB, significantly increasing the cellular immune response and inhibiting the growth of M. tuberculosis.
Therapeutic effects of traditional Chinese medicine Niubeixiaohe in mouse tuberculosis models.
Immunogenicity and therapeutic effects of a Mycobacterium tuberculosis rv2190c DNA vaccine in mice
Non-infected mice immunized with rv2190c DNA or ag85a DNA showed higher levels of interferon-gamma (IFN-γ) in stimulated spleen lymphocyte culture supernatants, and had more Th1 cells and an elevatory ratio of Th1/Th2 immune cells in whole blood, indicating that Th1-type immune response was predominant.
Ag85A/ESAT-6 chimeric DNA vaccine induces an adverse response in tuberculosis-infected mice
The results of the present study suggested that the ESAT-6 antigen is not suitable for inclusion in therapeutic vaccines, in contrast with previous results, which indicated that DNA vaccines expressing the individual antigens were either beneficial or at least not harmful.
Immune responses to a recombinant Rv0057-Rv1352 fusion protein of Mycobacterium tuberculosis.
Results suggest that Rv0057-Rv1352 has potential for the serodiagnosis of active pulmonary TB.