X. Z. Wu

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LEOPARD syndrome (LS) is an autosomal dominant "RASopathy" that manifests with congenital heart disease. Nearly all cases of LS are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), non-receptor type 11 (PTPN11) gene that encodes the SH2 domain-containing PTP-2 (SHP2). RASopathies typically affect components of the(More)
BACKGROUND Cryptopleurine, a phenanthroquinolizidine alkaloid, was known to exhibit anticancer activity; however, the underlying mechanism is poorly understood. Because the nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and development and progression of cancer, we investigated the(More)
As we all know, singularity is commonly encountered in parallel mechanisms. It is shown that the behavior of singularity of parallel mechanisms could be more complicated than that of serial ones. However, it is not very clear whether singularity will bring problems to kinematics, dynamics or other characteristics and what result will be caused when parallel(More)
Mammalian gene expression patterns change profoundly in response to low oxygen levels. These changes in gene expression programs are strongly influenced by post-transcriptional mechanisms mediated by mRNA-binding factors: RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we review the RBPs and miRNAs that modulate mRNA turnover and translation in(More)
Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden death in children and young adults. Abnormalities in several signaling pathways are implicated in the pathogenesis of HCM, but the role of the RAS-RAF-MEK-ERK MAPK pathway has been controversial. Noonan syndrome (NS) is one of several autosomal-dominant conditions known as RASopathies, which are(More)
Fluoroscopic contrast resolution is commonly determined at a specified kVp by imaging a test object comprised of targets where contrast decreases gradually and sequentially. Threshold contrast or contrast resolution is the contrast of the lowest contrast target that can be perceived. This approach suffers from two problems. First, test object contrast is(More)
Surface tension measurements reveal surface freezing in liquid n-alkanes. A solid monolayer of molecules is found to exist up to 30 degrees C above the bulk freezing point. This surface phase exists only for carbon numbers 14 n </= 50. The measured carbon number and temperature dependence of the surface tension is interpreted within a simple thermodynamical(More)
A new water-soluble receptor 1 has been synthesized and it showed selective recognition of zwitterionic arginine in aqueous media. Moreover, the receptor 1 could be regard as a facile tool for protein labeling and quantitative determination (LOD = 15 nM).
A new high-performance surface-enhanced Raman scattering (SERS) substrate with extremely high SERS activity was produced. This SERS substrate combines the advantages of Au film over nanosphere (AuFON) substrate and Ag nanoparticles (AgNPs). A three order enhancement of SERS was observed when Rhodamine 6G (R6G) was used as a probe molecule to compare the(More)