X. Y. Hou

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Transient ischemia increases tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor. Several tyrosine kinases are involved in this process. In this study, effect of ischemia and reperfusion (I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src and Pyk2, with NR2A was investigated.(More)
It has been reported that the Src family kinases-mediated tyrosine phosphorylation of alpha(1C) subunits of L-type voltage-gated calcium channels (L-VGCCs) potentiates the channel currents. In this study, we evaluated the alterations in the tyrosine phosphorylation level of alpha(1C) and in the interactions involving Src/Fyn, alpha(1C) and PSD-95 in the(More)
AIM To investigate the mechanism underlying dopaminergic neurotoxicity in the striatum during anoxia. METHODS Using rat striatal slices as an in vitro model, the activity of Ca2+-calmodulin-dependent protein kinase II (CCDPKII) was examined by the method of substrate phosphorylation 32P-incorporation. RESULTS Anoxia for 30 min greatly reduced CCDPKII(More)
Dopamine(DA) is a neurotransmitter, but it also serves as a neurotoxin under certain pathological conditions. Accumulating evidences indicate that DA plays an important role in ischemic cerebral damage. The mechanism by which DA exacerbates the neuronal damage remains unclear. Many mechanisms have been proposed to explain the DA neurotoxicity. One(More)
  • H W Zhang, S W Yin, L J Zhang, X Y Hou, Y Y Wang, G S Zhang
  • 2015
Transcriptome sequencing technology has been applied in the development and discovery of single nucleotide polymorphism (SNP) markers in fish. In this study, a panel of 120 expressed sequence tag (EST)-derived SNPs was selected by several selection filters from the resultant EST library of Odontobutis potamophila using Illumina Sequencing. In total, 37 SNPs(More)
AIM To study the effect of dopamine receptor antagonists on anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus and striatum. METHODS Using the rat hippocampal and striatal slices under 95% N2 + 5% CO2, the activity of CCDPK II was examined by 32P-incorporation. RESULTS Under anoxia for 30(More)
AIM To study the effect of dopamine (DA) on Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus. METHODS Using rat hippocampal slices as an in vitro model, the activity of CCDPK II was examined by the method of 32P-incorporation. RESULTS Exogenous DA reduced CCDPK II activity in hippocampal slices in a concentration- and(More)
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