X. Y. Hou

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The present study was designed to determine to determine the in vitro affinity profile of (R)-(-)-dimethindene and (S)-(+)-dimethindene at muscarinic receptor subtypes using both functional and binding assays. In addition, the racemate was investigated in functional studies. The functional muscarinic receptors studied were putative M1 receptors in rabbit(More)
Dopamine(DA) is a neurotransmitter, but it also serves as a neurotoxin under certain pathological conditions. Accumulating evidences indicate that DA plays an important role in ischemic cerebral damage. The mechanism by which DA exacerbates the neuronal damage remains unclear. Many mechanisms have been proposed to explain the DA neurotoxicity. One(More)
AIM To investigate the mechanism underlying dopaminergic neurotoxicity in the striatum during anoxia. METHODS Using rat striatal slices as an in vitro model, the activity of Ca2+-calmodulin-dependent protein kinase II (CCDPKII) was examined by the method of substrate phosphorylation 32P-incorporation. RESULTS Anoxia for 30 min greatly reduced CCDPKII(More)
AIM To study the effect of dopamine receptor antagonists on anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus and striatum. METHODS Using the rat hippocampal and striatal slices under 95% N2 + 5% CO2, the activity of CCDPK II was examined by 32P-incorporation. RESULTS Under anoxia for 30(More)
AIM To study the effect of dopamine (DA) on Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus. METHODS Using rat hippocampal slices as an in vitro model, the activity of CCDPK II was examined by the method of 32P-incorporation. RESULTS Exogenous DA reduced CCDPK II activity in hippocampal slices in a concentration- and(More)
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