Learn More
Large-conductance Ca2+- and voltage-dependent potassium (BK) channels exhibit functional diversity not explained by known splice variants of the single Slo alpha-subunit. Here we describe an accessory subunit (beta3) with homology to other beta-subunits of BK channels that confers inactivation when it is coexpressed with Slo. Message encoding the beta3(More)
AIMS To investigate whether the relative abundance of the Bacteroidetes and Firmicutes divisions in pigs is different between obese and lean animals. METHODS AND RESULTS Group-specific primers were designed to target the 16S rRNA genes of Bacteroidetes and Firmicutes present in the gut. After the validation of their specificity, these primers were used in(More)
A family of accessory beta subunits significantly contributes to the functional diversity of large-conductance, Ca(2+)- and voltage-dependent potassium (BK) channels in native cells. Here we describe the functional properties of one variant of the beta subunit family, which confers properties on BK channels totally unlike any that have as yet been observed.(More)
  • X. Xia
  • IEEE Trans. Automat. Contr.
  • 2002
Online estimation of the frequencies of a signal which is the sum of sinusoidals with unknown amplitudes, frequencies and phases is made through yet another well-known and simple system theoretical tool—adaptive identifiers. Convergence of the proposed estimator is proved. The new frequency estimator is of 3 order, as compared to the order 5 1 resulting(More)
Presenilin 1 (PS1) is required for the proteolytic processing of Notch and the beta-amyloid precursor protein (APP), molecules that play pivotal roles in cell-fate determination during development and Alzheimer's disease pathogenesis, respectively. In addition, PS1 interacts with beta-catenin and promotes its turnover through independent mechanisms.(More)
A measurement of the energy dependence of antineutrino disappearance at the Daya Bay reactor neutrino experiment is reported. Electron antineutrinos (ν¯(e)) from six 2.9  GW(th) reactors were detected with six detectors deployed in two near (effective baselines 512 and 561 m) and one far (1579 m) underground experimental halls. Using 217 days of data, 41(More)
This paper presents a review of the achievements of the optimal power dynamic dispatch problem since its inception to the present. There exist two formulations for this problem in the literature. The first formulation is the optimal control dynamic dispatch (OCDD), where the power system generation has been modelled as a control system and optimization is(More)
[1] The meteorological mechanisms for lofting trace gases and aerosols out of the planetary boundary layer (PBL) into the free troposphere are key to understanding local air pollution problems as well as regional and global atmospheric chemistry and climate issues. Over the North American continent, convective storms and lifting in warm conveyor belts(More)
This study aims to investigate the significance of erythropoietin-producing hepatocellular (Eph)A2 expression and the mechanism by which EphA2 is involved in the epithelial-mensenchymal transition (EMT) of gastric cancer cells. EphA2 expression levels were upregulated and positively correlated with metastasis and EMT markers in human gastric cancer(More)