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In this paper we describe a new algorithm for nonrigid registration of brain images based on an elastically deformable model. The use of registration methods has become an important tool for computer-assisted diagnosis and surgery. Our goal was to improve analysis in various applications of neurology and neurosurgery by improving nonrigid registration. A(More)
BACKGROUND qualitative and quantitative changes in human mitochondrial DNA (mtDNA) have been implicated in various cancer types. A 4,977 bp deletion in the major arch of the mitochondrial genome is one of the most common mutations associated with a variety of human diseases and aging. METHODS we conducted a comprehensive study on clinical features and(More)
When heterogeneous congestion control protocols that react to different pricing signals share the same network, the current theory based on utility maximization fails to predict the network behavior. The pricing signals can be different types of signals such as packet loss, queueing delay, etc, or different values of the same type of signal such as(More)
Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identify cancer patients with low enzyme(More)
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