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Loss of heterozygosity (LOH) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carcinoma of the head and neck (SCCHN), DNAs from both normal muscle(More)
OBJECTIVE To study the specific mechanism of NUMB regulate tumor proliferation. METHODS A stable cell line by knocking down NUMB in Hela was eatablished and the Western blot and qRT-PCR was applied to confirm the knocking out of NUMB. The effect on tumor proliferation in the absence of NUMB was investigated by observing tumor growth in nude mice. The(More)
The short arm of chromosome 8 is frequently lost in many human carcinomas including breast cancer, suggesting the presence of a tumor suppressor gene(s) in this region. We identified a gene termed hEXT1L/EXTR1/EXTL3 (hEXT1L hereinafter) that was mapped to chromosome bands 8p12-p21 where frequent LOHs of this region was reported in breast cancer. The(More)
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