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MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways
TLDR
MiR-100 and miR-99a have critical roles in altering cellular processes by targeting both the FKBP51 and IGF1R/mTOR signalling pathways in vitro and might represent a potential novel strategy for ALL treatment. Expand
MiR-129-5p is downregulated in breast cancer cells partly due to promoter H3K27m3 modification and regulates epithelial-mesenchymal transition and multi-drug resistance.
TLDR
There is a reciprocal regulation between miR-129-5p and SoX4 via the SOX4/EZH2 complex mediated H3K27me3 modification in breast cancer cells. Expand
Genome-wide screen identified let-7c/miR-99a/miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma
TLDR
Findings showed potential links between miRNAs and inflammation, and provide a potential treatment strategy for developing an miRNA-based therapy via IL-6/STAT3 targeting for CCA. Expand
Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary
TLDR
It is concluded that estrogen up-regulates the expression level of L RP16 mRNA through activation of ERalpha and that overexpression of LRP16 promotes MCF-7 cell proliferation probably by increasing cyclin E. Expand
Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas
TLDR
Findings provide strong evidence of the oncogenic activity of AHI-1 in human leukemogenesis and demonstrate that its deregulation may contribute to the development of Sezary syndrome. Expand
Effects of upregulation of Id3 in human lung adenocarcinoma cells on proliferation, apoptosis, mobility and tumorigenicity
TLDR
For the first time both in vitro and in vivo proofs are provided that forced expression of Id3 in lung adenocarcinoma cells reduces tumor growth rate and may be a potential target for tumor suppression. Expand
METTL3 promotes the progression of nasopharyngeal carcinoma through mediating M6A modification of EZH2.
TLDR
Investigation of whether METTL3 promoted the progression of nasopharyngeal carcinoma by silencing CDKN1C through EZH2 revealed that it was highly expressed in NPC cell lines, including SUNE-1 and C666-1, and survival analysis demonstrated that patients with higher expression ofMETTL3 exhibited significantly longer overall survival time than those with lower METTL2 expression. Expand
Expression and prognostic roles of magnesium-dependent phosphatase-1 in gastric cancer.
  • Y. Chen, J. Lin, +8 authors G. Chen
  • Medicine
  • European review for medical and pharmacological…
  • 1 June 2017
TLDR
Down-regulation of MDP-1 expression was a predictor of a poor prognosis for gastric cancer patients, and it may refer to tumor cells that have lost a protective enzymatic system. Expand
MicroRNA-23b suppresses cervical cancer biological progression by directly targeting six1 and affecting epithelial-to-mesenchymal transition and AKT/mTOR signaling pathway.
OBJECTIVE To elucidate the effects and mechanism of microRNA-23b (miR-23b) in cervical cancer (CC) progression. PATIENTS AND METHODS Fifty-six pairs of CC tissue samples and matched para-carcinomaExpand
TSG-6 Induces Apoptosis of Human Hypertrophic Scar Fibroblasts via Activation of the Fas/FasL Signalling Pathway.
TLDR
Increased expression of TSG-6 may induce apoptosis of human hypertrophic scar fibroblasts via activation of the Fas/FasL signalling pathway. Expand
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