X. J. Guo

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(-)-Stepholidine (SPD) is an antagonist of normosensitive dopamine (DA) receptors, but it exhibits D1 agonistic action on rotational behaviour in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta (SNC). In the present study, agonistic and antagonistic effects of SPD on the DA receptor-mediated synaptosomal(More)
Although permanent bilateral common carotid artery occlusion (2VO) has been demonstrated to induce retinal injury, there is still a lack of systematic research on the complex processing of retinal degeneration. In the present study, time-dependent (at three, 14, 60 days after 2VO surgery) changes of neurotrophic and inflammatory systems, as well as(More)
A total of 288 crossbred (Duroc×Landrace×Yorkshire) growing pigs were used in two experiments to investigate the effects of adding β-mannanase to corn-soybean meal-based diets on pig performance and apparent total tract digestibility (ATTD). Both experiments lasted 28 d and were split into two phases namely 1 to 14 days (phase 1) and 15 to 28 days (phase(More)
The effects of lappaconitine (LA) and N-deacetyllappaconitine (DLA) on footshock-induced analgesia (FSIA) were studied by the rat tail flick test. Rats subjected to 90 s nonescaping footshock had a significant increase in tail flick latency. Naloxone (4 micrograms, i.c.v.) partially antagonized the FSIA. After 5 consecutive exposures to footshock, rats(More)
In the rat tail flick test, ip LA 6 mg/kg, icv DLA 60 micrograms and icv or with morphine 5 micrograms exhibited significant analgesia. But with either LA 40 micrograms or DLA 60 micrograms was inactive. Naloxone (4 micrograms icv) which antagonized morphine analgesia failed to alter the analgesia induced by LA and DLA. Microinjection of DLA 20 micrograms(More)
The permanent occlusion of common carotid arteries (2-VO) in rats has been shown to induce progressive and long-lasting deficits in cognitive performance, however, whether these aberrant behaviors are attributed to visual dysfunction or cognitive impairment and what are the underlying mechanisms, remain controversial. In the present study, vision dominant(More)
Monoaminergic neurotransmitter 5-hydroxytryptamine (5-HT), also known as serotonin, plays important roles in modulating the function of the olfactory system. However, thus far, the knowledge about 5-HT and its receptors in olfactory receptor neurons (ORNs) and their physiological role have not been fully characterized. In the present study, reverse(More)
AIM The mechanical character of diaphragm muscle after chronic electrical stimulation(CES) and effect of the extracellular Ca2+ change have not yet been explored. We wondered whether there might be great different change and effect on muscle mechanics after CES and the extracellular Ca2+ change. METHODS The twitch tension(Pt), time to peak tension(TPT),(More)
There are many different elementary intracellular calcium signalling in the cell. These events appear to have a hierarchical organization depending on stimulus intensity. Low levels of stimulation activate individual channels such as the blips or quarks; The next level of organization is the puffs and sparks, which appear to be derived from small clusters(More)