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Sorafenib and S-1 (one mixed formulation containing 5-FU prodrug and dihydropyrimidine dehydrogenase inhibitor) were two effective agents against hepatocellular carcinoma (HCC), but whether they had synergistic effects remained unclear. The present study aimed at evaluating their synergistic effects against HCC and its mechanisms. Inhibitory effects of(More)
AIM To investigate the effects of class I phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 on the invasiveness and related mechanisms of implanted tumors of SGC7901 human gastric carcinoma cells in nude mice. METHODS Nude mice were randomly divided into model control groups and LY294002 treatment groups. On days 5, 10 and 15 after treatment, the(More)
Urine release (micturition) serves an essential physiological function as well as a critical role in social communication in many animals. Here, we show a combined effect of olfaction and social hierarchy on micturition patterns in adult male mice, confirming the existence of a micturition control center that integrates pro- and anti-micturition cues.(More)
At present, small number imprinted genes have been reported in cattle compare to human and mouse. Maternally expressed gene 8 (Meg8), a non-coding gene, have been identified maternally expressed in mouse and sheep, but its sequences and imprinting status have not been established in cattle. In this study, the full-length of cattle Meg8 cDNA sequence was(More)
Algorithms derived from measurements of short-peptide (8-10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K(b), can bind well over 1 million different peptides with significant affinity (<500 nM), a level of ligand-binding promiscuity approaching the level of heat shock protein binding of unfolded(More)
DNA methylation plays an important role in maintaining pluripotency and regulating the differentiation of stem cells, but the DNA methylation profile of stem cells in hepatocellular carcinoma (HCC) remains unclear. To investigate the genome-wide DNA methylation profile of side population (SP) cells of HCC, a special subpopulation of cells enriched with(More)
In this paper, by employing a fixed-point theorem in cones, we study a kind of higher-dimension impulsive functional differential equation with parameter as follows: x' = A(t)x(t) + lambdaf(t, x<sub>t</sub>), t npar tau<sub>k</sub>, Deltax|<sub>t</sub> <sub>=</sub> <sub>tau</sub> <sub>k</sub> = I<sub>k</sub>(x(tau<sub>k</sub>)), t = tau<sub>k</sub>, k isin(More)
We examined the genomic variability of 26 wild-type 1 polioviruses isolated from 12 provinces in China from 1985-1993. The poliovirus genome region that encodes the N-terminal portion of the VP1 protein was amplified by the polymerase chain reaction (PCR). The PCR product of each isolate was analysed by restriction fragment length polymorphism (PCR-RFLP)(More)
DNA hypermethylation plays important roles in carcinogenesis by silencing key genes. This study aims to identify pivotal genes in hepatocellular carcinoma (HCC) by DNA methylation microarray and to assess their prognostic values. DNA methylation microarray was performed in 45 pairs of HCC and adjacent nontumorous tissues and six normal liver tissues to(More)
Simvastatin has inhibitory effects on cancers. The present study aimed to investigate the interactive effects between simvastatin and S-1 against bile duct cancer and its mechanisms. The effects of simvastatin and 5-fluorouracil (5-FU) alone or in combination on the growth and apoptosis of the human cholangiocarcinoma cell line EGI-1 and the gallbladder(More)