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The retinal protein Nrl belongs to a distinct subfamily of basic motif-leucine zipper DNA-binding proteins and has been shown to bind extended AP-1-like sequence elements as a homo- or heterodimer. Here, we demonstrate that Nrl can positively regulate the expression of the photoreceptor cell-specific gene rhodopsin. Electrophoretic mobility-shift analysis(More)
Proteins of the Maf/Nrl subfamily of bZIP transcription factors are involved in the regulation of tissue-specific gene expression. The Nrl gene, initially identified from a subtracted retinal library, is expressed in all cell layers of the adult retina, including photoreceptors. The Nrl protein has high sequence homology with Maf proteins, binds to an AP-1(More)
The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology--excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on(More)
Using a sample of 58 million J/ψ events recorded in the BESII detector, the decay J/ψ → ωπ + π − is studied. There are conspicuous ωf 2 (1270) and b 1 (1235)π signals. At low ππ mass, a large broad peak due to the σ is observed, and its pole position is determined to be (541 ± 39)-i (252 ± 42) MeV from the mean of six analyses. The errors are dominated by(More)
We present a measurement of the azimuthal asymmetries of two charged pions in the inclusive process e^{+}e^{-}→ππX, based on a data set of 62  pb^{-1} at the center-of-mass energy of 3.65 GeV collected with the BESIII detector. These asymmetries can be attributed to the Collins fragmentation function. We observe a nonzero asymmetry, which increases with(More)
The two-photon transition c ð3686Þ ! J=c is studied in a sample of 1:06 Â 10 8 c ð3686Þ decays collected by the BESIII detector. The branching fraction is measured to be ð3:1 AE 0:6ðstatÞ þ0:8 À1:0 ðsystÞÞ Â 10 À4 using J=c ! e þ e À and J=c ! þ À decays, and its upper limit is estimated to be 4:5 Â 10 À4 at the 90% confidence level. This work represents(More)
a r t i c l e i n f o a b s t r a c t We extract the e + e − → π + π − cross section in the energy range between 600 and 900 MeV, exploiting the method of initial state radiation. A data set with an integrated luminosity of 2.93 fb −1 taken at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider is used. The cross section is(More)
Using 1.09×10^{9} J/ψ events collected by the BESIII experiment in 2012, we study the J/ψ→γη^{'}π^{+}π^{-} process and observe a significant abrupt change in the slope of the η^{'}π^{+}π^{-} invariant mass distribution at the proton-antiproton (pp[over ¯]) mass threshold. We use two models to characterize the η^{'}π^{+}π^{-} line shape around 1.85 (More)