Wun Chen Lee

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We previously identified a protein (p67) in the yeast, Saccharomyces cerevisiae, that specifically recognizes nuclear localization sequences. We report here the partial purification of p67, and the isolation, sequencing, and disruption of the gene (NSR1) encoding this protein. p67 was purified using an affinity column conjugated with a peptide containing(More)
Human glycogen synthase kinase-3 alpha (GSK-3 alpha) is a serine/threonine kinase that phosphorylates a variety of cytoplasmic and nuclear proteins. It also phosphorylates components of the neuronal cytoskeleton including tau and neurofilament heavy chain. Hyperphosphorylated tau is found in neurofibrillary tangles, a hallmark of Alzheimer's disease and(More)
Many storage tanks used in industry are inspected manually in order to identify leakage and corrosion. This repetitive task can harm the operator as the operator has to expose themselves to danger inside the tank. The environment of the tank can be harmful because it might contain highly hazardous substances. Additionally, the manual inspection process also(More)
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