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OBJECTIVE To investigate the safety, pharmacokinetics (PK), binding activity and immunogenicity of CR002, a human monoclonal antibody (mAb) directed against platelet-derived growth factor-D (PDGF-D), administered as a single intravenous (i.v.) infusion over a range of doses. SUBJECTS 40 healthy male subjects received increasing doses of CR002 at 0.3, 1,(More)
The aim of this work was to measure the safety and efficacy of single i.v. doses of dolasetron mesilate for the control of emesis caused by single high-dose (at least 6 Gy) radiotherapy to the upper abdomen. The double-blind, placebo-controlled, multicenter study stratified patients on the basis of being naive or nonnaive to radiotherapy. Patients with or(More)
Relations between vegetation characteristics and eco-hydrological processes were assessed in a pristine mire in the valley of the Ob River (Western Siberia). Along a transect from the terrace scarp to the river, field data were collected on vegetation composition, peat stratigraphy, peat chemistry, hydrology and hydrochemistry. Based on floristic(More)
Pancreatico-biliary diversion (PBD) stimulates pancreatic growth in the rat. The present experiment was designed to investigate the mechanism of this phenomenon. The potential roles of endogenous CCK, gastrin, and secretin were studied. Hormone measurements by specific RIA's show that PBD was associated with higher CCK plasma concentrations and, conversely,(More)
Woody plants growing in seasonal climates normally form one growth ring each year. However, under severe stress conditions they may not complete annual wood production all the way down to the root collar resulting in continuouslymissing outer rings at lower stem sections (CMORs). Herewe testwhether CMORs occur at different distributional margins of woody(More)
6537 Background: Oral mucositis (OM) is a commonly occurring side effect of high-dose chemotherapy (HDCT) in patients (pts) undergoing autologous hematopoietic stem cell transplant (AHSCT). Velafermin, recombinant human fibroblast growth factor 20, is being investigated for prevention of OM. Velafermin promotes epithelial and mesenchymal cell proliferation(More)
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