Dilution assays are quantal dose-response assays that detect a positive or negative response in each individual culture within groups of replicate cultures that vary in the dose of cells/organisms tested. We propose three jackknife versions of the maximum likelihood estimator of the unknown parameter, i.e., the frequency of a well-defined cell within theâ€¦ (More)

As a research program, â€˜bounded rationalityâ€™ aims to understand the actual cognitive processes that humans use to arrive at their behavioral repertoire. The assumptions of bounded rationality depart from the traditional assumptions of omniscient, â€˜Laplacean Demonsâ€™ with unlimited information, time and processing ability, and instead assume that individualsâ€¦ (More)

A recently described design method for one-parameter biomedical models such as limiting or serial dilution assays is generalized to two-parameter models for which the dose-response relationship can be expressed as a linear regression model with parameters alpha (intercept) and beta (slope). Design formulae are proposed for three different cases in whichâ€¦ (More)