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Transcriptional activation of HIV by Mycobacterium tuberculosis in human monocytes
The effect of M. tuberculosis and its PPD on HIV replication in monocytes is primarily one of transcriptional activation, and using an adenovirus infection system containing an HIV long‐terminal repeat (LTR) reporter plasmid, this effect correlated with production of tumour necrosis factor‐alpha in monocyte cultures. Expand
Modulation of Transforming Growth Factor β‐1 Gene Expression by Interleukin‐12
The critical role of IL‐12 in the early activation of the immune response to pathogens may include down‐modulation of TGF‐β1 gene activity, as found in the human lines, K562 and A549. Expand
Antibodies to adult human endothelial cells cross‐react with oxidized low‐density lipoprotein and β2‐glycoprotein I (β2‐GPI) in systemic lupus erythematosus
The data indicate that EC share antigenic epitopes with β2‐GPI and with oxLDL, especially LPC, and the findings indicate the potential role of both lipid oxidation and phospholipase A2 in SLE. Expand
Degradation of HK 2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
Autophagy is an important degradative mechanism that delivers select cytoplasmic components into the lysosome for recycling purposes (Mizushima and Komatsu, 2011). Activation of autophagy promotesExpand
Advances in Brief Overexpression of cdc 25 A and cdc 25 B Is Frequent in Primary Non-Small Cell Lung Cancer but Is Not Associated with Overexpression of c-myc 1
Cyclin-dependent kinases can be activated by cdc25, which removes inhibitory phosphates from tyrosine and threonine residues. At least three cdc25 genes (cdc25A, cdc25B, and cdc25C) have beenExpand
A TL1 Team Approach to CNS-Localized Delivery of Glial Cell-Derived Neurotrophic Factor for Treatment of Parkinson’s Disease*
OBJECTIVES/GOALS: Develop a strategy to restrict GDNF diffusion at an injected CNS tissue site for dopamine neuron rescue by endowing it with binding affinity for carbohydrates that are abundant onExpand
A DEMETER-like DNA demethylase protein governs tomato
70 In plants, genomic DNA methylation which contributes to development and stress 71 responses can be actively removed by DEMETER-like DNA demethylases (DML). 72 Indeed, in Arabidopsis DMLs areExpand
MyD88/PI3-K/NF-κB pathway mediates the antagonism of lipoxin A_4 on LPS-induced synthesis of interleukins in endothelial cells
LXA4 inhibits synthesis of IL-1β, IL-6 and IL-8 by down-regulation of PI3-K/NF-κB and AP-1 signal pathway in PMVEC. Expand