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Recruitment and positioning determine the specific role of the XPF‐ERCC1 endonuclease in interstrand crosslink repair
XPF‐ERCC1 is a structure‐specific endonuclease pivotal for several DNA repair pathways and, when mutated, can cause multiple diseases. Although the disease‐specific mutations are thought to affectExpand
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The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair
Abstract A key step in the Fanconi anemia pathway of DNA interstrand crosslink (ICL) repair is the ICL unhooking by dual endonucleolytic incisions. SLX4/FANCP is a large scaffold protein that plays aExpand
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Xenopus egg extract: A powerful tool to study genome maintenance mechanisms.
DNA repair pathways are crucial to maintain the integrity of our genome and prevent genetic diseases such as cancer. There are many different types of DNA damage and specific DNA repair mechanismsExpand
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A high priority shipment : How nuclease delivery by SLX4 mediates DNA interstrand crosslink repair
DNA interstrand crosslinks (ICLs) are lesions on the DNA that covalently attach both strands of the double helix. ICLs are very toxic to cells since important cellular processes such as DNAExpand