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The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned(More)
Recombination is the exchange of information between two homologous chromosomes during meiosis. The rate of recombination per nucleotide, which profoundly affects the evolution of chromosomal segments, is calculated by comparing genetic and physical maps. Human physical maps have been constructed using cytogenetics, overlapping DNA clones and radiation(More)
The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the(More)
—Task scheduling and core mapping have a significant impact on the overall performance of network on chip (NOC). In this paper, a unified task scheduling and core mapping algorithm called UNISM is proposed for different NOC architectures including regular mesh, irregular mesh and custom networks. First, a unified model combining scheduling and mapping is(More)
We have placed 7,600 cytogenetically defined landmarks on the draft sequence of the human genome to help with the characterization of genes altered by gross chromosomal aberrations that cause human disease. The landmarks are large-insert clones mapped to chromosome bands by fluorescence in situ hybridization. Each clone contains a sequence tag that is(More)
In this paper, we present a partitioning, mapping, and routing optimization framework for energy-efficient VFI (Voltage-Frequency Island) based Network-on-Chip. Unlike the recent work [10] which only performs partitioning together with voltage-frequency assignment for a given mesh network layout, our framework consists of three key VFI-aware components,(More)
In this paper, we propose a novel and global A3MAP (Architecture-Aware Analytic Mapping) algorithm applied to NoC (Networks-on-Chip) based MPSoC (Multi-Processor System-on-Chip) not only with homogeneous cores on regular mesh architecture as done by most previous mapping algorithms but also with heterogeneous cores on irregular mesh or custom architecture.(More)
A novel method for in vitro calibration of skin hydration measurements is presented. The method combines gravimetric and electrical measurements and reveals an exponential dependency of measured electrical susceptance to absolute water content in the epidermal stratum corneum. The results also show that absorption of water into the stratum corneum exhibits(More)
Dopamine transporter scans of some patients who have been clinically diagnosed with Parkinson's disease (PD) fail to reveal abnormal dopaminergic functioning and are referred to as scans without evidence of dopaminergic deficits (SWEDDs). In this study, we investigated the differences between SWEDDs patients and PD patients using(More)
The mnd2 mutation on mouse chromosome 6 produces a progressive neuromuscular disorder. To determine the gene content of the 400-kb mnd2 nonrecombinant region, we sequenced 108 kb of mouse genomic DNA and 92 kb of human genomic sequence from the corresponding region of chromosome 2p13.3. Three genes with the indicated sizes and intergenic distances were(More)