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Crystal structure of human DGCR8 core

• Sun Young Sohn, Won Jin Bae, Jeong Joo Kim, K. W. Yeom, Victoria Kim, Y. Cho
• Nature Structural &Molecular Biology
• 2007

A complex of Drosha with DGCR8 (or its homolog Pasha) cleaves primary microRNA (pri-miRNA) substrates into precursor miRNA and initiates the microRNA maturation process. Drosha provides the catalytic… (More)

Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors.

• Bulat I. Khayrutdinov, Won Jin Bae, +14 authors Y. Cho
• Protein science : a publication of the Protein…
• 2009

In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. The C-terminal domain of mouse Cdt1 (mCdt1C), the most conserved region in… (More)

Label-free electrochemical detection of the p53 core domain protein on its antibody immobilized electrode.

• Jongchan Yeo, Jin-Young Park, +4 authors Su-Moon Park
• Analytical chemistry
• 2009

We report quantitative results on interactions between a tumor suppressor protein, p53, also known as a prognostic cancer marker, and its antibody. The p53 antibody molecules immobilized on an… (More)

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the central zinc-binding domain of the human Mcm10 DNA-replication factor.

• Nam Young Jung, Won Jin Bae, Jeong Ho Chang, Young Chang Kim, Y. Cho
• Acta crystallographica. Section F, Structural…
• 2008

The initiation of eukaryotic DNA replication requires the tightly controlled assembly of a set of replication factors. Mcm10 is a highly conserved nuclear protein that plays a key role in the… (More)

Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein.

• Jung Min Choi, Sung Yun Kang, Won Jin Bae, Kyeong Sik Jin, Moonhor Ree, Y. Cho
• The Journal of biological chemistry
• 2007

Werner syndrome is a premature aging disease caused by mutations in the WS gene and a deficiency in the function of Werner protein (WRN). The lack of WRN results in a cellular phenotype of genomic… (More)

Upregulation of HGF and c-MET is Associated with Subclinical Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

• Bon Seok Koo, Jin-man Kim, +6 authors Young Chang Lim
• Annals of Surgical Oncology
• 2014

Identification of a novel biomarker of subclinical lymph node metastasis (SLNM) in papillary thyroid microcarcinoma (PTMC) could provide important clues regarding SLNM in PTMC. We evaluated the… (More)

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