Won Hyeok Choe

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BACKGROUND & AIMS The molecular mechanisms by which hepatitis C virus (HCV) antagonizes the antiviral actions of interferon (IFN) have not been fully characterized. Specifically, how HCV proteins impact on IFN signaling components has yet to be elucidated. We used an HCV cell-based expression model to examine the interaction between HCV protein expression(More)
We developed hepatitis C virus (HCV) core-E1-E2 and HCV core transgenic mice on a common genetic background to assess the contribution of HCV structural proteins to hepatocarcinogenesis. Eight-week-old core-E1-E2, core, and nontransgenic mice inbred on the FVBxC57Bl/6 background were treated with diethylnitrosamine (DEN) and sacrificed at 32 weeks old.(More)
BACKGROUND/AIMS Although a small amount of fecal material can obscure significant colorectal lesions, it has not been well documented whether bowel preparation status affects the missing risk of colorectal polyps and adenomas during a colonoscopy. METHODS We prospectively enrolled patients with one to nine colorectal polyps and at least one adenoma of >5(More)
BACKGROUND A paucity of information exists regarding colorectal neoplasm in asymptomatic, average-risk individuals 40 to 49 years of age. OBJECTIVE To evaluate the prevalence and risk factors of colorectal neoplasms in those in their 40s. DESIGN Cross-sectional study. SETTING Results offered to subjects of a health care provider that offers screening(More)
The studies concerning the association between Helicobacter pylori status and colorectal adenoma, premalignant lesions of colorectal cancers, are not consistent. This cross-sectional study investigated the association of colorectal adenoma with H. pylori infection in a consecutive series of 2,195 asymptomatic average-risk subjects who underwent screening(More)
Ki Tae Suk, Soon Koo Baik, Jung Hwan Yoon, Jae Youn Cheong, Yong Han Paik, Chang Hyeong Lee, Young Seok Kim, Jin Woo Lee, Dong Joon Kim, Sung Won Cho, Seong Gyu Hwang, Joo Hyun Sohn, Moon Young Kim, Young Bae Kim, Jae Geun Kim, Yong Kyun Cho, Moon Seok Choi, Hyung Joon Kim, Hyun Woong Lee, Seung Up Kim, Ja Kyung Kim, Jin Young Choi, Dae Won Jun, Won Young(More)
AIM To investigate hepatic function after combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) with a short-term interval (0-2 d). METHODS A total of 115 patients with compensated liver cirrhosis underwent RFA combined with TACE at a time-interval of 0-2 d for the treatment of hepatocellular carcinoma (HCC) < 5.0 cm.(More)
BACKGROUND The efficacy of entecavir (ETV) monotherapy in treatment-experienced patients with chronic hepatitis B (CHB) is debatable. METHODS A total of 22 hepatitis B e antigen (HBeAg)-positive CHB patients who had shown viral breakthrough or suboptimal response with lamivudine (3TC) and adefovir disoproxil (ADV) therapy were treated with 1.0 mg of ETV.(More)
OBJECTIVE Partial virologic response (PVR) in chronic hepatitis B (CHB) patients during antiviral therapy is associated with an increased risk of occurrence of viral resistance and treatment failure. The aim of this study was to evaluate the clinical and virological responses of partial responders to long-term entecavir (ETV) monotherapy. MATERIAL AND(More)
A higher circulating vitamin D level is inversely associated with the risk of colorectal cancer, but the association with adenoma risk is less clear. We examined the association between the circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy. The(More)