• Publications
  • Influence
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells
Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo replicative senescence characterized by cell enlargement, loss of differentiation potential and ultimateExpand
  • 333
  • 10
Calcification or dedifferentiation: Requirement to lock mesenchymal stem cells in a desired differentiation stage
A current challenge in mesenchymal stem cell (MSC)‐based cartilage repair is to solve donor and tissue‐dependent variability of MSC cultures and to prevent chondrogenic cells from terminalExpand
  • 179
  • 8
Acute anoxia stimulates proliferation in adult neural stem cells from the rat brain
Hypoxic-ischemic damage is a major challenge for neuronal tissue. In the present study, we investigated the effects of anoxia and glucose deprivation on adult neural stem cells (NSCs) in vitro. WeExpand
  • 39
  • 5
Monitoring of cellular senescence by DNA‐methylation at specific CpG sites
Replicative senescence has fundamental implications on cell morphology, proliferation, and differentiation potential. Here, we describe a simple method to track long‐term culture based on continuousExpand
  • 84
  • 4
MicroRNAs are shaping the hematopoietic landscape
Hematopoiesis is regulated by microRNAs (miRNAs). These small regulatory RNAs are master regulators of developmental processes that modulate expression of several target genes post-transcriptionally.Expand
  • 112
  • 4
  • PDF
Senescence‐associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells
Replicative senescence has a major impact on function and integrity of cell preparations. This process is reflected by continuous DNA methylation (DNAm) changes at specific CpG dinucleotides in theExpand
  • 43
  • 4
  • PDF
Hematopoietic Stem and Progenitor Cells Acquire Distinct DNA-Hypermethylation During in vitro Culture
Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses stemness during culture. In this study, we compared DNA-methylation (DNAm)Expand
  • 28
  • 3
Adipogenic differentiation of human mesenchymal stromal cells is down‐regulated by microRNA‐369‐5p and up‐regulated by microRNA‐371
Long‐term culture of human mesenchymal stromal cells (MSC) has implications on their proliferation and differentiation potential and we have demonstrated that this is associated with up‐regulation ofExpand
  • 85
  • 2
Aging of hematopoietic stem cells is regulated by the stem cell niche
Adult stem cells provide the basis for regeneration of aging tissue. Their dual ability for self-renewal and multilineage differentiation is controlled by direct interaction with a specificExpand
  • 91
  • 2
The Link Between Epigenetic Clocks for Aging and Senescence
Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecularExpand
  • 14
  • 2
  • PDF