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Inhibition of fungal lanosterol-14 alpha-demethylase (CYP51) is the working principle of the antifungal activity of azoles used in agriculture and medicine. Inhibition of human CYP51 may result in endocrine disruption since follicular fluid-meiosis activating steroid (FF-MAS), the direct product of lanosterol demethylation, is involved in the control of(More)
Despite the fact that more than 5000 safety-related studies have been published on bisphenol A (BPA), there seems to be no resolution of the apparently deadlocked controversy as to whether exposure of the general population to BPA causes adverse effects due to its estrogenicity. Therefore, the Advisory Committee of the German Society of Toxicology reviewed(More)
In the last decade an important role for the progression of neuronal cell death in Alzheimer's disease (AD) has been ascribed to oxidative stress. trans-4-Hydroxy-2-nonenal, a product of lipid peroxidation, forms conjugates with a variety of nucleophilic groups such as thiols or amino moieties. Here we report for the first time the quantitation of(More)
The Outpatient Long-term Intensive Therapy for Alcoholics (OLITA) is a four-step program of care for severely affected chronic alcoholics which, after inpatient detoxification, extends over a total of 2 years. High-frequency short-term individual therapeutic contacts, initially daily, are followed by a slow tapering of individual contact frequency and(More)
  • J Pistrol, D Adam, S Villwock, W Völkel, F Kopf
  • 2014
Dynamic roller compaction has become the common method for near-surface compaction, because dynamic rollers are much more efficient compared to static rollers. Two types of excitation are mainly used for dynamic roller compaction, the vibratory and the os-cillatory roller. In the presented study the differences in functioning, mode of operation and loading(More)
While one of the authors of the editorial wrote in 2010 in Environmental Health Perspectives " biomonitoring studies should be used by regulatory agencies to assess human exposure levels " and further on " Center of Disease Control (CDC) analytical procedure … is the gold standard " (Vandenberg et al. 2010b), Vandenberg and Prins praise the studies of Hass(More)
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