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Bisphenol A (BPA) is a weak estrogen. Pharmacokinetic studies of BPA have demonstrated a rapid and extensive metabolism of BPA to the nonestrogenic BPA-monoglucuronide (BPA-gluc). Some investigators have reported that BPA was found at parts per billion concentrations in the tissues or urine of humans without known exposure to BPA. This work developed a(More)
Inhibition of fungal lanosterol-14 alpha-demethylase (CYP51) is the working principle of the antifungal activity of azoles used in agriculture and medicine. Inhibition of human CYP51 may result in endocrine disruption since follicular fluid-meiosis activating steroid (FF-MAS), the direct product of lanosterol demethylation, is involved in the control of(More)
In the last decade an important role for the progression of neuronal cell death in Alzheimer's disease (AD) has been ascribed to oxidative stress. trans-4-Hydroxy-2-nonenal, a product of lipid peroxidation, forms conjugates with a variety of nucleophilic groups such as thiols or amino moieties. Here we report for the first time the quantitation of(More)
While one of the authors of the editorial wrote in 2010 in Environmental Health Perspectives " biomonitoring studies should be used by regulatory agencies to assess human exposure levels " and further on " Center of Disease Control (CDC) analytical procedure … is the gold standard " (Vandenberg et al. 2010b), Vandenberg and Prins praise the studies of Hass(More)
to verify the earlier kinetic studies (Teeguarden et al. 2015; Thayer et al. 2015). All the results of the earlier kinetic studies were verified as described in a letter to the editor in Archives of Toxicology (Völkel 2017). In contrast, older biomonitoring studies reporting unchanged BPA in blood samples, for example, of pregnant women, could not be(More)
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