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Adenylosuccinase deficiency is an autosomal recessive inherited defect of purine synthesis. In enzyme deficient patients, two normally undetectable compounds, succinylaminoimidazole carboxamide riboside and succinyladenosine, accumulate in urine, cerebrospinal fluid and, to a minor extent, in plasma. Analysing 150 highly selected urine specimens from… (More)
Malabsorption appears common in patients with Down syndrome. We determined gliadin antibodies (IgG and IgA) in 78 children (aged 1-19 years) with Down syndrome and found increased IgG levels in 23, increased IgA levels in 2 and both increased IgG and IgA levels in 6 patients. Two patients with increased IgG and IgA had coeliac disease, two others had no… (More)
Endotracheal suctioning is a routine procedure in ventilated newborns. A study of ten neonates demonstrates the association of transient bacteremia with endotracheal suctioning. This complication in ventilated newborns, with colonization of the respiratory tract by the same organism, must be considered in the pathogenesis of systemic infection.
An increasing number of reports on Chlamydia trachomatis pneumonia in infancy has recently been published in the literature. The demonstration of the etiologic agent depends, however, on laborious culture procedures and serological techniques. Based on the observation of a cross-reaction between certain Acinetobacter species and chlamydiae, the detection of… (More)
Ultrasound real-time-B-mode-scanning of the brain in 100 severely ill preterm and term infants during intensive care. Technique of horizontal and sagittal scans by linear arrays (3.5 and 5 MHz) with a self-made flexible water-bath for improvement of contact between skull and probe. Normal scans in comparison to pathological findings like intracerebral,… (More)