Wolfgang R. Mueller

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The conversion of prion helix 1 from an alpha-helical into an extended conformation is generally assumed to be an essential step in the conversion of the cellular isoform PrPC of the prion protein to the pathogenic isoform PrPSc. Peptides encompassing helix 1 and flanking sequences were analyzed by nuclear magnetic resonance and circular dichroism. Our(More)
Histidine-containing protein (HPr) is a central metabolic sensor in low-GC Gram-positive bacteria and plays a dual role in sugar uptake by the phosphoenolpyruvate-sugar phosphotransferase system and in transcriptional control during carbon catabolite repression. The latter process is mediated by interaction between HPr and the carbon catabolite repression(More)
In this work, we developed a protein-specifically adapted scoring function and applied it to the reranking of protein-protein docking solutions generated with a conventional docking program. The approach was validated using experimentally determined structures of the bacterial HPr-protein in complex with four structurally nonhomologous binding partners as(More)
An alternative concept for the selective catalytic formation of 1-octene from ethylene via dimeric catalytic centers is proposed. The selectivity of the tetramerization systems depends on the capability of ligands to form binuclear complexes that subsequently build up and couple two separate metallacyclopentanes to form 1-octene selectively. Comparison of(More)