Wolfgang Meier

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With the advent of native and XML enabled database systems, techniques for efficiently storing, indexing and querying large collections of XML documents have become an important research topic. This paper presents the storage, indexing and query processing architecture of eXist, an Open Source native XML database system. eXist is tightly integrated with(More)
In the body, nanoparticles can be systemically distributed and then may affect secondary target organs, such as the central nervous system (CNS). Putative adverse effects on the CNS are rarely investigated to date. Here, we used a mixed primary cell model consisting mainly of neurons and astrocytes and a minor proportion of oligodendrocytes to analyze the(More)
Ht~rmann, A., W. Meier and J. Sehloen, A control architecture for an advanced fault-tolerant robot system, Robotics and Autonomous Systems 7 (1991) 211-225. A major issue in robotic research is the development of advanced autonomous robots which are able to solve a difficult task in a complex environment. Besides the need for powerful sensing and planning(More)
Silver nanoparticles (SNPs) are among the most commercialized nanoparticles worldwide. Often SNP are used because of their antibacterial properties. Besides that they possess unique optic and catalytic features, making them highly interesting for the creation of novel and advanced functional materials. Despite its widespread use only little data exist in(More)
Giant unilamellar vesicles or GUVs are systems of choice as biomimetic models of cellular membranes. Although a variety of procedures exist for making single walled vesicles of tens of microns in size, the range of lipid compositions that can be used to grow GUVs by the conventional methods is quite limited, and many of the available methods involve energy(More)
Pulmonary surfactant biophysical properties are best described by surface tension and surface viscosity. Besides lecithin, surfactant contains a variety of minor lipids, such as plasmalogens, polyunsaturated fatty acid-containing phospholipids (PUFA-PL), and cholesterol. Plasmalogens and cholesterol improve surface properties of lipid mixtures(More)
We present a DNA-containing polymeric nanocontainer using the self-assembled superstructure of amphiphilic block copolymers in aqueous solutions. To demonstrate that DNA translocation is possible across a completely synthetic block copolymer membrane, we have used a phage transfection strategy as a DNA-transfer model system. For this purpose the bacterial(More)
Triblock copolymeric nanoreactors are introduced as an alternative for liposomes as encapsulating carrier for prodrug activating enzymes. Inosine-adenosine-guanosine preferring nucleoside hydrolase of Trypanosoma vivax, a potential prodrug activating enzyme, was encapsulated in nanometer-sized vesicles constructed of(More)
A highly permeable yet highly selective pore-spanning biomimetic membrane embedded with aquaporin Z is molecularly designed and constructed via a combination of pressure-assisted vesicle adsorption and covalent-conjugation-driven vesicle fusion on a porous support. This approach represents a significant breakthrough in the architecture of biomimetic(More)