Wolfgang Kuhn

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Exogenous application of levodopa is conventionally used to equalize the striatal dopamine deficit in idiopathic Parkinson's disease (PD). The stimulation of endogenous biosynthesis of levodopa via activation of tyrosine hydroxylase (TH) has been proposed as new therapeutic concept in PD. This may be achieved by exogenous supply with the reduced coenzyme(More)
One main metabolizing pathway of levodopa is O-methylation to 3-O-methyldopa (3-OMD) by catechol-O-methyltransferase (COMT). Since COMT requires Mg2+ and S-adenosylmethionine as methyl donor for this transmethylating process, COMT converts S-adenosylmethionine to S-adenosylhomocysteine and subsequent homocysteine. Objective of this study was to demonstrate(More)
Sirs: A significant increased hazard ratio for both ischaemic heart and cerebrovascular disease was found in a cohort of 220 parkinsonian patients [2]. Mild hyperhomocysteinaemia has been suggested as a risk factor for atherosclerosis and vascular disease [9]. A significant elevation of plasma homocysteine in parkinsonian patients was found in comparison(More)
The upcoming Belle II experiment is designed to work at a luminosity of 8 &#x00D7; 10<sup>35</sup>cm<sup>-2</sup>s<sup>-1</sup>, 40 times higher than its predecessor. The pixel detector of Belle II with its ~8 million channels will deliver ten times more data than all other sub-detectors together. A data rate of 22 Gbytes/s is expected for a trigger rate of(More)
This paper focuses on the discovery and retrieval of geographic information. The specifications provided by the OpenGIS-Consortium (OGC) enable syntactic interoperability and cataloguing of geographic information. However, while OGC-compliant catalogues support discovery, organisation, and access of geographic information, they do not yet provide methods(More)
Background. The reduced form of coenzyme Q10 (CoQ10) acts as a lipophilic antioxidant and participates in electron and proton transport of the respiratory chain in the inner mitochondrial membrane. An alteration in CoQ10 redox state may thus reflect a change in membrane electron transport and the effectiveness of defense against toxic reactive oxygen(More)
Glutathione S-transferases (GSTs) are involved in the detoxification of endogenous or exogenous toxins, which may play a role in the pathogenesis of Parkinson's disease. We genotyped the Glutathione-S-Transferase isoenzymes GSTM1 and GSTT1 by polymerase chain reaction in order to evaluate different gene polymorphisms of these isoenzymes in 149 parkinsonian(More)
No significant increase of the maximum concentration (Cmax) of levodopa after addition of catechol-O-methyltransferase inhibitor tolcapone occurred in previous pharmacokinetic studies predominantly on healthy volunteers. We compared pharmacokinetics of levodopa in plasma before and after addition of tolcapone in 13 treated parkinsonian subjects under(More)
In the last few years, the genetic contribution to Parkinson’s disease has gained major attention and resulted in the identification of four gene loci in autosomal dominant and autosomal recessive Parkinson’s disease. Several mutations in two genes have been shown to be responsible for neuronal cell death in Parkinsons’s disease. One of the gene products(More)
PANDA is a new universal detector for antiproton physics at the HESR facility at FAIR/GSI. The PANDA data acquisition system has to handle interaction rates of the order of 10**7 /s and data rates of several 100 Gb Is. FPGA based compute nodes with multi-Gbit/s bandwidth capability using the ATCA architecture are designed to handle tasks such as event(More)