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In patients with squamous cell carcinomas of the oral cavity and the oropharynx the presence or absence of nodal metastases still is the most important predictive factor. The discriminative significance of extracapsular spread and the influence of features of the primary tumor—such as size and depth of invasion—on metastatic pattern, treatment failure and(More)
The borders of the parapharyngeal space are formed of fasciae of muscular tissue. Its lateral border is formed by the bone of the mandible, while its cranial border is formed by the petrous bone. The initial symptoms of parapharyngeal tumors are diagnostically volatile because of the soft tissue contents of the parapharyngeal borders. For diagnostic(More)
Patients with recurrent or refractory head and neck squamous cell carcinoma received cisplatin/epinephrine injectable gel or placebo gel injected directly into the clinically dominant tumour. The double-blind phase III trial comprised of up to 6 weekly treatments over 8 weeks, 4 weekly evaluation visits, and then monthly follow-up; open-label dosing began(More)
After standardizing surgical procedures around 1900 Shelden, Toye, Weinstein and Ciaglia developed the percutaneous dilational tracheotomy (PDT). At present it is recognized that about 50 % of the anesthesiological Intensive care Units (ICU) in Germany are using the PDT while favoring the Ciaglia-technique in the majority of cases. Further techniques are(More)
Tierexperimentelle Untersuchungen zeigen, dass durch Amifostin bei einer Einzeitbestrahlung eine Protektion der Speicheldrüsen erreicht werden kann. Der dosismodifizierende Faktor wird für die Spättoxizität mit 2,3 angegeben. Ob durch die zusätzliche Amifostinmedikation bei der Bestrahlung von Kopf-Hals-Tumoren die Intensität der Mukositis und der(More)
Anhand einer retrospektiven Studie analysierten die Autoren die Therapie und den Verlauf von 438 Patienten, die sich im Zeitraum von 1988–1994 an der Universitäts-HNO-Klinik Hamburg-Eppendorf aufgrund einer malignen neoplastischen Erkrankung der chirurgischen Sanierung zervikaler Lymphabflußwege unterzogen. Ergebnisse: Bei 337 Patienten (76,9%) erfolgte(More)
Der vielfach dokumentierte prognostische Einfluss der Infiltrationstiefe von Mundhöhlen- und Oropharynxkarzinomen sollte anhand fortgeschrittener bereits lymphogen metastasierter Tumoren untersucht und dieses mit den etablierten Einflussgrößen T-Kategorie und Kapselruptur von Lymphknotenmetastasen verglichen werden. Der 5-jährige postoperative Verlauf von(More)
BACKGROUND Based on a new histo-morphological rating scheme, we assessed the impact on patient prognosis of lymph node metastasis of squamous cell carcinoma (SCC) in the head/neck area. Special attention was given to possible capsular rupture. METHOD In a retrospective study, 111 patients with squamous cell carcinoma of the head and neck with concomitant(More)
To examine the influence of the hemorrheologic agent pentoxifylline (PTX) on tumor oxygenation and radiosensitivity. Tumor oxygenation in rat rhabdomyosarcomas R1H after PTX administration (50 mg/kg body weight) was measured using interstitial pO2 probes (Licox CMP system and Eppendorf pO2-Histograph). Tumors were irradiated with 60Co γ-irradiation using(More)
OBJECTIVE To determine the safety and efficacy of targeted antitumor therapy with cisplatin/epinephrine injectable gel in patients with advanced squamous cell carcinoma of the head and neck. DESIGN Two prospective, double-blind, placebo-controlled phase III trials of identical design. Crossover from blinded to open-label phase was permitted for patients(More)