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PURPOSE To evaluate the efficacy and safety of a dexamethasone implant (Ozurdex) alone or in combination with bevacizumab. METHODS Sixty-four eyes were prospectively investigated. Group 1 (22 central retinal vein occlusion (CRVO) and 16 branch retinal vein occlusion (BRVO)) was treated with Ozurdex alone, and group 2 (14 CRVO and 12 BRVO) was treated with(More)
PURPOSE To report on epiretinal membrane (ERM) characteristics and photoreceptor layer integrity of lamellar macular holes (LMHs) and macular pseudoholes (MPHs), and to compare with clinical course in operated and untreated eyes. METHODS We consecutively reviewed the charts of patients with LMH and MPH between 2003 and 2013. For clinical analysis, we(More)
A system for the determination of oxalic acid in human urine using ion exchange-ion pair, high performance liquid chromatography with electrochemical detection (HPLCEC) is described. Urine is acidified with HCl, and excess CaCl2 is added to precipitate oxalate ion. The precipitate is isolated, redissolved in dilute sulfuric acid, and separated on a strong(More)
PURPOSE To compare immunocytochemical and ultrastructural characteristics of "lamellar hole-associated epiretinal proliferation" in lamellar macular holes with "conventional epiretinal membrane" in macular pseudoholes. DESIGN A consecutive observational case series, laboratory investigation. METHODS We analyzed surgically excised flat-mounted internal(More)
The pathogenesis of central serous chorioretinopathy (CSC) is still poorly understood. An animal model of CSC proved that the mineralocorticoid receptor [1] of the choroid also plays a role in CSC. Since there is still no evidence-based therapy for non-self-limiting CSC, this case series evaluates the effect of oral spironolactone in CSC patients. In this(More)
PURPOSE To evaluate cell death and ultrastructural effects on capsulotomy specimens derived from femtosecond laser-assisted cataract surgery. METHODS In 26 eyes, an anterior capsulotomy was performed using a femtosecond laser. In 10 eyes (group 1), the laser-pulse energy was set to 15 μJ using a rigid curved interface and in another 10 eyes (group 2) to 5(More)
PURPOSE To study the microanatomic edge structures of anterior lens capsule specimens derived from manual and femtosecond laser-assisted capsulotomies. SETTING Department of Ophthalmology, Goethe-University, Frankfurt, Germany. DESIGN Experimental study. METHODS Of 60 eyes with lens removal and intraocular lens implantation, 30 received a manual(More)
To ascertain the morphological changes in the edge structure of femtosecond laser-derived capsulotomy specimens using varying patient interfaces and different laser pulse energies. In this experimental clinical study femtosecond laser-assisted capsulotomies were performed in 30 eyes using the LenSx femtosecond laser (LenSx, Alcon, Fort Worth, TX, USA).(More)
Posterior capsule opacification (PCO) is the most frequent complication after cataract surgery, leading to a loss of sight if untreated. Erlotinib might be of therapeutic interest as an effective target agent (selective EGF-tyrosin-kinase-1 inhibitor). In this in-vitro study, erlotinib was evaluated for ocular biocompatibility and its effect on cell(More)
PURPOSE To analyze the correlation between morphological and functional results 12 months after epiretinal membrane (ERM) surgery. METHODS 31 eyes from 31 consecutive patients with metamorphopsia and best corrected visual acuity (BCVA) below 20/32 underwent a transconjunctival 23- gauge vitrectomy with ERM and internal limiting membrane peeling.(More)