Wolfgang Dietl

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BACKGROUND Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS Immune function of viable peripheral blood mononuclear cells (PBMC) was evaluated(More)
Cardiac diseases such as myocardial infarction and heart failure are among the leading causes of death in western societies. Therapeutic angiogenesis has been suggested as a concept to combat these diseases. The biology of angiogenic factors expressed in the heart such as vascular endothelial growth factor (VEGF) is well studied, whereas data on(More)
The endothelium of coronary arteries has been identified as an important organ locally regulating coronary perfusion and cardiac function by paracrine secretion of nitric oxide (NO) and other vasoactive mediators. Therefore, the established organ procurement in cardiac transplantation using hypothermic storage solutions designed to preserve myocytes but not(More)
OBJECTIVE Ischemia/reperfusion injury caused by cardioplegic arrest is still a major challenge in patients with reduced left ventricular function. We investigated the effect of chronic versus acute administration of the selective endothelin-A receptor antagonist (ERA) TBC-3214Na during ischemia/reperfusion in failing hearts. METHODS Male Sprague-Dawley(More)
Experimental animal models of brain death increasing intracranial pressure (ICP) by inflating an intracranial placed balloon-catheter are well established and used in transplant-associated studies. Our aim was to develop an experimental mouse model of brain death (BD) and to compare explosive and gradual brain death induction under ICP monitoring. We(More)
RATIONALE Acute lung injury (ALI) is a serious condition in critically ill patients that predisposes to secondary bacterial pneumonia. Vascular leak is a hallmark in the pathogenesis of ALI. The fibrin-derived peptide Bbeta(15-42) was shown to preserve endothelial barriers, thereby reducing vascular leak. The potential therapeutic role of Bbeta(15-42) in(More)
AIM The aim of this paper was to improve operative outcome during open-heart surgery in patients with failing hearts, the composition of cardioplegic solutions has to be further optimized. HTK-N46b, a novel cardioplegic solution, has been developed for efficient protection of the energy state of myocytes as well as endothelial cells. Aim of this study is(More)
BACKGROUND Previous work on endothelial dysfunction in post-MI heart failure has shown conflicting results. AIM To analyze gender related alterations in NO-, PGI(2)- and EDHF-dependent endothelial function in the thoracic aorta 7 and 42 days after myocardial infarction (MI). METHODS AND RESULTS MI was induced by coronary artery ligation in female and(More)
In einem geographisch sehr heterogenen Gebiet bestehend aus wenigen flachen Talsohlen, in welchen die Ballungsräume Bozen, Leifers, Meran, Bruneck und Brixen liegen, und langen Tälern bis in die Höhe von Passübergängen und Talschlüssen, stellt die Versorgung mit Notfallmedizin und Krankentransporten an Politik, Auftraggeber und Ausführende besondere(More)
GRUNDLAGEN: Welche Patientengruppe am ehesten von der Off-Pump-Chirurgie profitiert, wird sehr kontrovers diskutiert. Diese prospektive, randomisierte Studie untersucht diese Operationsmethode an Patienten mit deutlich herabgesetzter linksventrikulärer Auswurffraktion (EF). METHODIK: Von 51 Patienten mit einer EF < 35 % wurden 26 mit der Off-Pump-Methode(More)