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BACKGROUND Since its first publication in 2000, the BONN-Risk-Index (BRI) has been successfully used to determine the calcium oxalate (CaOx) crystallization risk from urine samples. To date, a BRI-measuring device, the "Urolizer", has been developed, operating automatically and requiring only a minimum of preparation. Two major objectives were pursued:(More)
Emotional stress is associated with e.g. increased hormone release, high blood-sugar level and blood pressure. Stress clearly affects metabolism. Whether chronic stress exposure leads to altered urinary compositions with increased risk of CaOx; urolithiasis was examined by investigating the relation between stress burden and urine composition. 29 controls(More)
This review draws the recent state of the art in metabolic diagnosis and metaphylaxis of stone disease. It is the basis for the consensus approval with the other medical societies and institutions in Germany involved in the guideline process of the new “Urolithiasis Guideline”. The German Working Committee on Stone Disease reviewed critically the current(More)
In vitro investigations of the formation of Whewellite or Weddellite are described. By means of different precipitation models the influence of cationic minerals on the formation of Weddellite could be observed. The possible conversion of Weddellite into Whewellite in vivo is demonstrated by in vitro experiments. A theory of the formation of Weddellite or(More)
In profile urines from oxalate stone patients and normal persons the progress of concentration and excretion of 10 urine parameters was investigated. For the majority of lithogenic and litholytic urine substances, especially for oxalic acid, a day-and-night rhythm was proven. This may be transferred to a principle of zonary structure of weddellite crystals,(More)
For five test samples of the fourth International Ring Test to check the quality of methods for urinary calculus analysis, 45 findings obtained by 10 different methods were sent from 16 countries. The mean deviation of 0.11 molecular parts per component for all five samples is considerably low. The average standard $$\overline {SQ} $$ for all participants(More)
Information on autonomic modulation can be derived from different organs that are innervated by the sympathetic and the parasympathetic nervous system, when assessing e.g. heart rate or blood pressure fluctuations or the pupil's reaction to light. Correlations between parameters from different target organs might reveal information on hierarchically higher(More)
Crystal formation reflects the entire composition of the surrounding solution. In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis. If the progression of a disease is associated with characteristic changes(More)
The BONN Risk Index (BRI) successfully determines the calcium oxalate (CaOx) crystallization risk from urine samples. The BRI is based on a standardized crystallization test performed on native urine. A BRI-measuring device, the “Urolizer®”, has been developed, operating automatically and requiring only a minimum of preparative efforts. In this study, the(More)