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  • Michael H. Glickman, David M. Rubin, +6 authors Daniel Finley
  • Medicine, Biology
  • Cell
  • 1998 (First Publication: 1 September 1998)
  • The proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP), which selects ubiquitinated substrates for translocation into the CP. An eight-subunit subcomplexContinue Reading
  • Ohad Medalia, Igor Weber, Achilleas S. Frangakis, Daniela Nicastro, Gunther Gerisch, Wolfgang Baumeister
  • Medicine, Biology
  • Science
  • 2002 (First Publication: 8 November 2002)
  • Electron tomography of vitrified cells is a noninvasive three-dimensional imaging technique that opens up new vistas for exploring the supramolecular organization of the cytoplasm. We applied thisContinue Reading
  • Pia Unverdorben, Florian Beck, +5 authors Friedrich Förster
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2014 (First Publication: 24 March 2014)
  • Significance The 26S proteasome is a multisubunit molecular machine for the targeted degradation of intracellular proteins. It has an essential role in the maintenance of protein homeostasis. DuringContinue Reading