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- Anna Frumkin, Shiran Dror, +4 authors Anat Ben-Zvi
- Front. Mol. Biosci.
- 2014
Proteome stability is central to cellular function and the lifespan of an organism. This is apparent in muscle cells, where incorrect folding and assembly of the sarcomere contributes to disease and… (More)
- Éva Kevei, Wojciech Pokrzywa, Thorsten Hoppe
- FEBS letters
- 2017
Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis,… (More)
- Wojciech Pokrzywa, Thorsten Hoppe
- Worm
- 2013
The activity and assembly of various myosin subtypes is coordinated by conserved UCS (UNC-45/CRO1/She4p) domain proteins. One founding member of the UCS family is the Caenorhabditis elegans UNC-45… (More)
- Vishnu Balaji, Wojciech Pokrzywa, Thorsten Hoppe
- BioEssays : news and reviews in molecular…
- 2018
The insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) pathway is a pivotal genetic program regulating cell growth, tissue development, metabolic physiology, and longevity of multicellular… (More)
- Wojciech Pokrzywa, Thorsten Hoppe
- Oncotarget
- 2017
Aging is modulated by environmental and physiological changes, involving genetic pathways that are conserved from yeast cells to mammalian organisms. Notably, Insulin/IGF-like signaling (IIS)… (More)
- Wojciech Pokrzywa, Robin Lorenz, Thorsten Hoppe
- Worm
- 2017
The integrity of the cellular proteome is supported by quality control networks, which govern protein synthesis, folding, and degradation. It is generally accepted that an age-related decline in… (More)
- Pankaj Thapa, Nilesh Shanmugam, Wojciech Pokrzywa
- BioEssays : news and reviews in molecular…
- 2019
The fate of eukaryotic proteins, from their synthesis to destruction, is supervised by the ubiquitin-proteasome system (UPS). The UPS is the primary pathway responsible for selective proteolysis of… (More)